JNK2/SAPK1 Protein (GWB-2A7845)

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GWB-2A7845

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Description

Similarity: Contains 1 protein kinase domain.

Function: JNK2 isoforms display different binding patterns alpha-1 and alpha-2 preferentially bind to c-Jun whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

Additional Information

Name JNK2/SAPK1 Protein (GWB-2A7845)
Related Product Names Mitogen-activated protein kinase 9, EC 2.7.11.24, Stress-activated protein kinase JNK2, c-Jun N-terminal kinase 2, JNK-55, JNK2, JNK2A, JNK2B, PRKM9, JNK2BETA, p54aSAPK, JNK2ALPHA, MAPK9, SAPK1.; EC 2.7.11.24; Stress-activated protein kinase JNK2; c-Jun N
Description of Target SAPK1/JNK2 Human Recombinant (stress-activated protein kinase/c-jun kinase) is a non-glycosilated polypeptide having a molecular mass of 49.5 kDa. SAPK1/JNK2 is purified by proprietary chromatographic techniques.
Gene Symbol JNK2/SAPK1
Gene id 5601
Alias Symbols Mitogen-activated protein kinase 9, EC 2.7.11.24, Stress-activated protein kinase JNK2, c-Jun N-terminal kinase 2, JNK-55, JNK2, JNK2A, JNK2B, PRKM9, JNK2BETA, p54aSAPK, JNK2ALPHA, MAPK9, SAPK1, JNK2/SAPK1 Human, JNK2/SAPK1 Human Recombinan
Swissprot ID P45984
Protein Name Mitogen-activated protein kinase 9
Protein Accession Num NP_001128516.1
NCBI Acc Number NP_002743.3
Product Format JNK2/SAPK1 (1.3 mg/ml) is supplied in 50mM Tris-HCl, 100mM NaCl, 1mM DTT, 50% glycerol, pH 8. Physical appearance: Sterile Filtered clear solution.
Purity Greater than 95% as determined by SDS-PAGE.
Source E. coli
Format JNK2/SAPK1 (1.3 mg/ml) is supplied in 50mM Tris-HCl, 100mM NaCl, 1mM DTT, 50% glycerol, pH 8.5
Reconstitution and Storage Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. Avoid multiple freeze-thaw cycles.
Storage Store at 4 C if entire vial will be used within 2-4 weeks. Store, frozen at -20 C for longer periods of time.
Avoid multiple freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for GWB-2A7845
Intended Use Research Use Only
Additional Information No protease activity detectable, specific activity > 300 U*/mg (*1 U = 1 pmol/min transferred to c-jun (1-169) at 30C). Autophosphorylation < 5%.
:: Product Introduction: JUN N-terminal Kinase 2is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.