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Anti-mTOR pS2448 Antibody (GWB-269501)



100 ug
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Similarity: Contains 1 PI3K/PI4K domain.

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Function: Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.

Additional Information

Name Anti-mTOR pS2448 Antibody (GWB-269501)
Availability In Stock
Related Product Names Affinity Purified Anti-mTOR (phospho specific) (Rabbit); FK506-binding protein 12-rapamycin complex-associated protein 1; Rapamycin target protein; RAPT1; Mammalian target of rapamycin; mTOR FRAP; FRAP2Anti-mTOR pS2448FRAP1
CB Species Human
Gene Symbol MTOR
Gene Fullname Serine/threonine-protein kinase mTOR
Gene id 2475
Swissprot ID P42345
Protein Name Serine/threonine-protein kinase mTOR
Protein Accession Num NP_004949.1; XP_005263495.1
Nucleotide Accession Num NM_004958.3; XM_005263438.1
Clone Polyclonal
Host Rabbit
Immunogen The immunogen for anti-FRAP1 antibody: this affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 2440-2457 of human mTOR.
Homology Human
NCBI Acc Number NP_004949.1
Product Format Liquid (sterile filtered)
Application IHC, ELISA, WB, IP
Format Liquid (sterile filtered)
Reconstitution and Storage Store vial at -20 C prior to opening.   This product is stable for several weeks at 4 C as an undiluted liquid.   Dilute only prior to immediate use.   For extended storage aliquot contents and freeze at -20 C or below.   Avoid cycles of freezing and thawing.   Expiration date is one (1) year from date of opening product.
Reactivity Human, Bovine, Mouse, Rat
Application Info ELISA: 1:15,000 - 1:65,000 WB: 1:500 - 1:2,000 IHC: 5.0 ug/ml
Storage -20C or Colder
Datasheets/Manuals Printable datasheet for GWB-269501
Species Reactivity Human
Intended Use Research Use Only
Key Reference Kristof,A.S. et al. (2003) Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin. J. Biol. Chem. 278 (36), 33637-33644.Chen,Y., et al. (2003) Phospholipase D confers rapamycin resistance in human breast cancer cells. Oncogene 22 (25), 3937-3942.Nojima,H. et al. (2003) The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. J. Biol. Chem. 278 (18), 15461-15464.
Additional Information Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
:: Label: Unconjugated
Preservative: 0.01% (w/v) Sodium Azide
Stabilizer: None