mTOR, Antibody

GWB-58F78E

20-786-255888

1 ml
$468.00

Description

Isotype: Rabbit IgG Positive Control: A431 and Jurkat cells

Cellular Localization: Cell membrane and cytoplasmic

Immunogen: A synthetic peptide corresponding to human mTOR protein. mTOR, or FKBP12-rapamycin associated protein (FRAP), is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 245-kD protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin-dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression.

Additional Information

Name mTOR, Antibody
Related Product Names RABBIT ANTI-mTOR POLYCLONAL ANTIBODY mTOR
Source Rabbit
Applications WB
Clonality Polyclonal
Format 1 ml affinity purified rabbit polyclonal antibody at 0.2mg/ ml in 10mM PBS, pH 7.4 with BSA and Sodium Azide.
Reactivity Human
Storage Ab with sodium azide is stable for al least 12 months when stored at 2-8C.
Datasheets/Manuals Printable datasheet for GWB-58F78E
Intended Use Research Use Only