Anti- mTOR (Phospho-Ser2448) Antibody

GWB-9C5F02

18-785-210287

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Description

Binding Site: Ser2448 WB Dilution: 500~1000

IHC Dilution: 50~100 Function: Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex.

Subunit: Interacts with the FKBP12-rapamycin complex. Binds UBQLN1.

Tissue Specificity: Expressed in numerous tissues, with highest levels in testis.

Similarity: Belongs to the PI3/PI4-kinase family.

Similarity: Contains 1 FAT domain.

Similarity: Contains 1 FATC domain.

Similarity: Contains 7 HEAT repeats.

Similarity: Contains 1 PI3K/PI4K domain. [1] Brown E.J., Albers M.W., Shin T.B., Ichikawa K., Keith C.T., Lane W.S., Schreiber S.L.
A mammalian protein targeted by G1-arresting rapamycin-receptor complex.
[2] Onyango P., Lubyova B., Gardellin P., Kurzbauer R., Weith A.
Molecular cloning and expression analysis of five novel genes in chromosome 1p36.
[3] Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., et al.
The DNA sequence and biological annotation of human chromosome 1.
[4] Stover C., Endo Y., Takahashi M., Lynch N., Constantinescu C., Vorup-Jensen T., Thiel S., Friedl H., Hankeln T., Hall R., et al.
The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.
[5] Chiu M.I., Katz H., Berlin V.
RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.
[6] Wu S., Mikhailov A., Kallo-Hosein H., Hara K., Yonezawa K., Avruch J.
Characterization of ubiquilin 1, an mTOR-interacting protein.
[7] Choi J., Chen J., Schreiber S.L., Clardy J.
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.
[8] Liang J., Choi J., Clardy J.
Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.

Additional Information

Name Anti- mTOR (Phospho-Ser2448) Antibody
Related Product Names FK506-binding protein 12-rapamycin complex-associated protein 1; Rapamycin target protein; RAPT1; Mammalian target of rapamycin; mTOR FRAP; FRAP2mTOR (Phospho-Ser2448)mTOR
Swissprot ID P42345
Molecular Weight 288892
Purity Affinity Purified
Source Rabbit
Applications IHC
Clonality Polyclonal
Format In PBS, 0.02% sodium azide and 50% glycerol.
Stability 1 year at -20C
Reactivity Human, Mouse, Rat
Storage 4C for short term (weeks) and -20C for long term. Avoid frequent freeze and thaw.
Datasheets/Manuals Printable datasheet for GWB-9C5F02
Intended Use Research Use Only