Neuropeptide Y (13-36) Human (GWB-29AECB)



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Sequence: {PRO} {ALA} {GLU} {ASP} {MET} {ALA} {ARG} {TYR} {TYR} {SER} {ALA} {LEU} {ARG} {HIS} {TYR} {ILE} {ASN} {LEU} {ILE} {THR} {ARG} {GLN} {ARG} {TYR}NH2 C Terminal: NH2

Formula: C134H207N41O36S1 The C-terminal NPY fragment (13-36)[NPY-(13-36)]. a Y2 receptor agonist. elicits vasopressor responses upon central administration. The cardiovascular responses of NPY-(13-36) together with the distribution of NPY receptor subtypes within the nucleus tractus solitarius (nTS) have therefore been studied in spontaneously hypertensive rats (SHR).Neuropeptide Y (13-36)(NPY 13-36) stimulates both Y2 and Y5 NPY receptor subtypes. but causes no increase in food intake even when injected at high doses. while the full length NPY is one of the most potent physiological stimulants of feeding yet described. It inhibits retinotectal transfer in amphibians.

Function: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

Subcellular Location: Secreted protein.

Tissue Specificity: One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.

Similarity: Belongs to the NPY family. [1] Coiro,V., Chiodera,P., Melani,A., Manfredi,G., Saccani Jotti,G. and Casti,A.
Different plasma neuropeptide Y concentrations in women athletes with and without menstrual cyclicity
[2] Colton,C.A. and Vitek,M.P., et al.
NPY and chronic neurodegenerative disease
[3] Dutton,M.A., Lee,E.W. and Zukowska,Z., et al.
NPY and extreme stress: lessons learned from posttraumatic stress disorder
[4] Feuerstein,G.Z. and Lee,E.W., et al.
Neuropeptide Y and the heart: implication for myocardial infarction and heart failure
[5] Edvinsson,L., et al.
Neuropeptide Y and the cerebral circulation
[6] Minth C.D., Bloom S.R., Polak J.M., Dixon J.E.
Cloning, characterization, and DNA sequence of a human cDNA encoding neuropeptide tyrosine.
[7] Minth C.D., Andrews P.C., Dixon J.E.
Characterization, sequence, and expression of the cloned human neuropeptide Y gene.
[8] Takeuchi T., Gumucio D.L., Yamada T., Meisler M.H., Minth C.D., Dixon J.E., Eddy R.E., Shows T.B.
Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7.
[9] Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., et al.
The DNA sequence of human chromosome 7.
[10] Allen J.M., Polak J.M., Bloom S.R.
Presence of the predicted C-flanking peptide of neuropeptide Y (CPON) in tissue extracts.

Additional Information

Name Neuropeptide Y (13-36) Human (GWB-29AECB)
Related Product Names Neuropeptide Y (13-36) HumanNPY
Swissprot ID P01303
NCBI Acc Number NP_000896.1
Molecular Weight 10851
Purity > 95%
GI Number 4505449
Stability 6-12 months at -20 degree C.
Reactivity Human
Sequence Length 97
Storage 4 degree C for short term (weeks) and -20 degree C for long term.
Datasheets/Manuals Printable datasheet for GWB-29AECB
Intended Use Research Use Only