peroxisome proliferative activated receptor gamma coactivator 1 alpha (PPARGC1A) Antibody (GWB-E81C5D)



1 ml


Clone: PPARAH6

IGG Subclass: IgG1 Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane. Summary: The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [1] Rangwala,S.M., Li,X., Lindsley,L., Wang,X., Shaughnessy,S., Daniels,T.G., Szustakowski,J., Nirmala,N.R., Wu,Z. and, et al.
Estrogen-related receptor alpha is essential for the expression of antioxidant protection genes and mitochondrial function
[2] Finck,B.N. and Kelly,D.P., et al.
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease
[3] Mortensen,O.H., Dichmann,D.S., Abrahamsen,N., Grunnet,N. and Nishimura,E.
Identification of a novel human glucagon receptor promoter: regulation by cAMP and PGC-1alpha
[4] Myles,S., Hradetzky,E., Engelken,J., Lao,O., Nurnberg,P., Trent,R.J., Wang,X., Kayser,M. and Stoneking,M.
Identification of a candidate genetic variant for the high prevalence of type II diabetes in Polynesians
[5] Stefan,N., Thamer,C., Staiger,H., Machicao,F., Machann,J., Schick,F., Venter,C., Niess,A., Laakso,M., Fritsche,A. and, et al.
Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention
[6] Endo H.
Isoform of PGC-1 generated by alternative splicing.

Additional Information

Name peroxisome proliferative activated receptor gamma coactivator 1 alpha (PPARGC1A) Antibody (GWB-E81C5D)
Related Product Names Mouse monoclonal anti-human PPARGC1A antibody; N/A LEM6; PGC1; PGC1A; PGC-1v; PPARGC1;PGC-1(alpha)peroxisome proliferative activated receptor, gamma,coactivator 1, alpha (PPARGC1A)PPARGC1A
Swissprot ID Q3LIG1
NCBI Acc Number NP_037393.1
Molecular Weight 0.5
Source Mouse
Application DB
GI Number 7019499
Clonality Monoclonal
Format Mouse monoclonal anti-human PPARGC1A antibody in PBS (3.0 mM KCl, 1.5 mM K2HPO4, 140 mM NaCl, 8.0 mM Na2HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3)
Reactivity Human
Sequence Length 798
Storage Store at 2-8 C for up to one year. We recommend storing at –20 C for long-term storage. Avoid repeat freezing and thawing cycles.
Datasheets/Manuals Printable datasheet for GWB-E81C5D
Intended Use Research Use Only