PPAR?: Human Recombinant E Coli (GWB-30F977)

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GWB-30F977

10-731-288187

10ug
$249.00
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Description

Similarity: Contains 1 nuclear receptor DNA-binding domain.

Buffer: PBS, 50% glycerol This nuclear receptor functions as a transcription factorand plays an important role in controlling differentiation and fatty acid metabolism. Activation of this receptor appears to be vital in modulating the expression of metabolic control proteins and consequently controlling fatty acid metabolism in cardiac muscle. This markermay be a useful drug target for therapeutic intervention incardiac disease. PPAR? is also involved in thepatho genesis of important metabolic disorders such asobesity and non-insulin-dependent diabetes (NIDDM).

Function: Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids.

Additional Information

Name PPAR?: Human Recombinant E Coli (GWB-30F977)
Related Product Names Peroxisome Proliferator-Activated Receptor, ?-isotype; PPAR-alpha; Nuclear receptor subfamily 1 group C member 1 NR1C1; PPARPPAR?: Human, Recombinant, E ColiPPARA
Immunogen This nuclear receptor functions as a transcription factor and plays an important role in controlling differentiation and fatty acid metabolism. Activation of this receptor appears to be vital in modulating the expression of metabolic control proteins and consequently controlling fatty acid metabolism in cardiac muscle. This marker may be a useful drug target for therapeutic intervention in cardiac disease. PPAR gamma is also involved in the pathogenesis of important metabolic disorders such as obesity and non-insulin-dependent diabetes (NIDDM). Genway Biotech recombinant human PPAR gamma is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use
Swissprot ID Q07869
NCBI Acc Number NP_001001928.1
Product Format Liquid.
Molecular Weight 59. 2kDa
Purity >95% by SDS-PAGE
Application SDS-Page
Format Liquid
Storage -20C
Datasheets/Manuals Printable datasheet for GWB-30F977
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Intended Use Research Use Only
Key Reference Schiffrin, E.L. et al. (2003) Hypertension. 42(4): 664-68.
:: Description: This nuclear receptor functions as a transcription factor and plays an important role in controlling differentiation and fatty acid metabolism. Activation of this receptor appears to be vital in modulating the expression of metabolic control proteins and consequently controlling fatty acid metabolism in cardiac muscle. This marker may be a useful drug target for therapeutic intervention in cardiac disease. PPAR gamma is also involved in the pathogenesis of important metabolic disorders such as obesity and non-insulin-dependent diabetes (NIDDM). Genway Biotech recombinant human PPAR gamma is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use