PPARG Protein (GWB-728440)

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GWB-728440

10-663-45547

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Description

Similarity: Contains 1 nuclear receptor DNA-binding domain.

Function: Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis.

Additional Information

Name PPARG Protein (GWB-728440)
Related Product Names Peroxisome proliferator-activated receptor gamma, PPAR-gamma, PPARG, NR1C3, PPARG1, PPARG2.; PPAR-gamma; Nuclear receptor subfamily 1 group C member 3 NR1C3PPAR-g HumanPPARG
Description of Target Recombinant Human Peroxisome Proliferator Activated Receptor Gamma
Gene Symbol PPARG
Gene Family NR
Gene id 5468
Alias Symbols Peroxisome proliferator-activated receptor gamma, PPAR-gamma, PPARG, NR1C3, PPARG1, PPARG2, PPARG Human, Peroxisome Proliferator Activated Receptor Gamma Human Recombinant
Swissprot ID P37231
Protein Name Peroxisome proliferator-activated receptor gamma
Protein Accession Num NP_005028.4
Host E. Coli
Peptide Sequence MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLYZ.
NCBI Acc Number NP_005028.4
Product Format PBS 50% glycerol, 0.01% azide. Physical appearance: Sterile Filtered clear solution.
Purity Greater than 95% as determined by SDS-PAGE. Mass spectrometry of tryptic digest products for identity determination.
Format PBS 50% glycerol, 0.01% azide.
Reconstitution and Storage Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. Avoid multiple freeze-thaw cycles.
Storage Store at 4 C if entire vial will be used within 2-4 weeks. Store, frozen at -20 C for longer periods of time.
Avoid multiple freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for GWB-728440
Intended Use Research Use Only
:: Product Introduction: The peroxisome proliferator activated receptors (PPARs) are ligandactivated transcription factors within the nuclear receptor superfamily, which play important roles in adipogenesis, glucose homeostasis andinflammation. Three different isotypes can be distinguished; alpha, beta and gamma. PPAR*, is mainly expressed in adipose tissue and to lesser extent in colon, the immune system and the retina. Whereas PPAR* operates in the catabolism of fatty acids in the liver, PPAR* influences the storage of fatty acids in the adipose tissue and plays a role in adipocyte differentiation. PPAR* binds to DNA as a heterodimer with retinoid X receptor (RXR), activating expression of target genes after binding ligand.
Product Description: Peroxisome Proliferator Activated Receptor Gamma Human Recombinant is expressed in E.coli having a molecular weight of 59.2 kDa and fused to an amino terminal hexahistidine tag.