PPARG Protein (GWB-7C168B)

GWB-7C168B

10-663-46047

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Description

Similarity: Contains 1 nuclear receptor DNA-binding domain.

Function: Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis.

Additional Information

Name PPARG Protein (GWB-7C168B)
Availability In Stock
Related Product Names Peroxisome proliferator-activated receptor gamma, PPAR-gamma, PPARG, NR1C3, PPARG1, PPARG2.; PPAR-gamma; Nuclear receptor subfamily 1 group C member 3 NR1C3PPARg-477 HumanPPARG
Gene Symbol PPARG (1-477)
Gene id 5468
Alias Symbols Peroxisome proliferator-activated receptor gamma, PPAR-gamma, PPARG, NR1C3, PPARG1, PPARG2, PPARG Human 1-477 a.a., Peroxisome Proliferator Activated Receptor Gamma Human Recombinant
Swissprot ID P37231
Protein Name Peroxisome proliferator-activated receptor gamma
Description of Target Recombinant Human Peroxisome Proliferator Activated Receptor Gamma (1-477)
Protein Accession Num NP_005028.4
Host E. Coli
NCBI Acc Number NP_005028.4
Product Format PPARG in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol. Physical appearance: Sterile Filtered clear solution.
Format PPAR-g protein at 0.1mg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol
Reconstitution and Storage Store vial at -20C to -80C. When stored at the recommended temperature, this protein is stable for 12 months. Avoid multiple freeze-thaw cycles.
Storage Store vial at -20 C to -80 C. When stored at the recommended temperature, this protein is stable for 12 months.
Avoid multiple freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for GWB-7C168B
Intended Use Research Use Only
:: Product Introduction: Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed peroxisome proliferators activated receptors (PPARs). Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPARs are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids.
Product Description: PPARG Human Recombinant encoding amino acids 1-477 expressed in E.coli, is fused to a GST tag and it is antibody reactive.The PPARG is purified by proprietary chromatographic techniques.