SOCS-3 Antibody (GWB-429200)



0.25 ml


Isotype: Rabbit IgG Positive Control: Liver, Testis.

Immunogen: A synthetic peptide corresponding to amino acids 209-225 of the human/rat/mouse SOCS 3. Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS 1, inhibition of signal transduction appears to occur by binding to and inhibiting the catalytic activity of members of JAK family of cytoplasmic kinases (direct JAK2 kinase inhibition). Biochemical characterization as well as gene disruption studies indicate that SOCS-1 is an important negative regulator of JAK-STAT signal pathway. Socs-1 is also called JAB SSI-1 or TIP3 (Tec-Interacting Protein).

Additional Information

Name SOCS-3 Antibody (GWB-429200)
Availability Discontinued
Related Product Names SOCS-3 RABBIT ANTIBODY SOCS-3
Source Rabbit
Application ELISA, WB, IP
Clonality Polyclonal
Format 0.25 ml affinity purified rabbit polyclonal antibody at 200ug/ ml in 10mM PBS, pH 7.4 with BSA and Sodium Azide.
Reactivity Human
Storage Ab with sodium azide is stable for 24 months when stored at 2-8C.
Datasheets/Manuals Printable datasheet for GWB-429200
Intended Use Research Use Only