SOCS-3 Antibody (GWB-5BDC5A)



7 ml


Isotype: Rabbit IgG Positive Control: Placenta and Testis

Cellular Localization: Cytoplasmic

Immunogen: Synthetic peptide corresponding to C-terminal of human SOCS-3 protein. Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.

Additional Information

Name SOCS-3 Antibody (GWB-5BDC5A)
Availability Discontinued
Related Product Names SOCS-3 RABBIT ANTIBODY SOCS-3
Source Rabbit
Application IHC-P
Format 7.0 ml prediluted antibody which is ready-to-use for staining of formalin-fixed, paraffin-embedded tissues.
Reactivity Human
Storage Ab with sodium azide is stable for 24 months when stored at 2-8C.
Datasheets/Manuals Printable datasheet for GWB-5BDC5A
Intended Use Research Use Only