SOCS-3 Antibody (GWB-E2C5D2)

GWB-E2C5D2

0.1 mg
$310.00
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Description

Short Description: MOUSE ANTI HUMAN SOCS-3

Additional Information

Name SOCS-3 Antibody (GWB-E2C5D2)
Availability In Stock
Related Product Names MOUSE ANTI HUMAN SOCS-3 SOCS-3
Gene Symbol SOCS3
Gene Family SH2D
Gene id 9021
Alias Symbols CIS3, SSI3, ATOD4, Cish3, SSI-3, SOCS-3, MGC71791, SOCS3
Swissprot ID O14543
Protein Name Suppressor of cytokine signaling 3
Description of Target MOUSE ANTI HUMAN SOCS-3
Protein Accession Num NP_003946.3
Clone SO1
Host Mouse
Isotype IgG2b
Replacement This antibody may replace item sc-41001 from Santa Cruz Biotechnology.
Immunogen The immunogen for anti-SOCS3 antibody: full - length SOCS3 protein.
Homology Human
NCBI Acc Number NP_003946.3
Product Format Purified IgG - liquid
Specificity SOCS-3
Concentration 1mg/ml
Application E, WB
GI Number 45439352
Clonality Monoclonal
Format Solution: Phosphate buffered saline, Stabalizer: 0.09%, Sodium Azide, Form: Purified IgG - liquid
Stability 18 months from date of despatch.
Reconstitution and Storage Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody.
Reactivity Human
Application Info Western Blot: This product detects a band of approximately 30kDa in Hela cell lysates.
Storage Store at +4C or at -20C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody.
Datasheets/Manuals Printable datasheet for GWB-E2C5D2
Species Reactivity Human
Intended Use Research Use Only
Key Reference 1. Lehmann, U. et al. (2003) SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. J Biol. Chem. 278(1): 661-671.
2. Suzuki, A. et al. (2001) CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J. Exp. Med. 193(4): 471-481.
3. Lang, R. et al. (2003) SOCS3 regulates the plasticity of gp130 signaling. Nature Immunology 4(6): 546-550.
4. Sakai, I. et al. (2002) Constitutive expression of SOCS3 confers resistance to IFN-alpha in chronic myelogenous leukemia cells. Blood 100(8): 2926-2930.
:: Preparation: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Preservative Stabilisers: 0.09% - Sodium Azide
:: Approx Protein Conc: Ig concentration 1.0 mg/ml
Buffer Solutions: Phosphate buffered saline pH7.4