SOCS-3 Antibody (GWB-FEE183)

GWB-FEE183

20-786-255829

1 ml
$468.00

Description

Isotype: Rabbit IgG Positive Control: Placenta and Testis

Cellular Localization: Cytoplasmic

Immunogen: Synthetic peptide corresponding to C-terminal of human SOCS-3 protein. Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.

Additional Information

Name SOCS-3 Antibody (GWB-FEE183)
Availability Discontinued
Related Product Names SOCS-3 RABBIT ANTIBODY SOCS-3
Source Rabbit
Application IHC-P
Clonality Polyclonal
Format 1 ml affinity purified rabbit polyclonal antibody at 200ug/ ml in 10mM PBS, pH 7.4 with BSA and Sodium Azide.
Reactivity Human
Storage Ab with sodium azide is stable for 24 months when stored at 2-8C.
Datasheets/Manuals Printable datasheet for GWB-FEE183
Intended Use Research Use Only