STAT3 Human (GWB-C35116)

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GWB-C35116

10-663-45559

$0.00

Description

Similarity: Contains 1 SH2 domain.

Function: Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

Additional Information

Name STAT3 Human (GWB-C35116)
Related Product Names Signal transducer and activator of transcription 3, Acute-phase response factor, STAT3, APRF, FLJ20882, MGC16063.; Acute-phase response factor APRFSTAT3 HumanSTAT3
Description of Target Recombinant Human STAT3
Gene Symbol STAT3
Gene Family SH2D
Gene id 6774
Alias Symbols Signal transducer and activator of transcription 3, Acute-phase response factor, STAT3, APRF, FLJ20882, MGC16063, STAT3 Human, STAT3 Human Recombinant
Swissprot ID P40763
Protein Name Signal transducer and activator of transcription 3
Protein Accession Num NP_003141.2
Host E. Coli
NCBI Acc Number NP_003141.2
Product Format STAT3 at 50ug/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol without BSA and Sodium Azide. Physical appearance: Sterile Filtered clear solution.
Format STAT3 at 50ug/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol without BSA and Sodium Azide.
Stability 1 week at 14 C. For longer periods of time store vial at -20 C to -80 C.
When stored at the recommended temperature, this protein is stable for 12 months.
Avoid multiple freeze-thaw cycles.
Reconstitution and Storage 1 week at 14C. For longer periods of time store vial at -20C to -80C. When stored at the recommended temperature, this protein is stable for 12 months. Avoid multiple freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for GWB-C35116
Intended Use Research Use Only
:: Product Introduction: STAT3 is tyrosine-phosphorylated and activated by a number of kinases. The binding of IL-6family cytokines(including IL-6, oncostatin Mand leukemia inhibitory factor) to the gp130receptor triggers STAT3 phosphorylation by JAK2. EGF-Rand certain other receptor tyrosine kinases, such as c-METphosphorylate STAT3 in response to their ligands. STAT3 is also a target of the c-srcnon-receptor tyrosine kinase. STAT3-deficient mouse embryoscan not develop beyond embryonic day 7 (E7.0), when gastrulation initiates. It appears that at these early stages of development, STAT3 activation is required for self-renewal of embryonic stem cells(ESCs). Indeed, LIF, which is supplied to ESC cultures to maintain their undifferentiatedstate, can be omitted if STAT3 is activated through some other means. Constitutive STAT3 activation is associated with various human cancers and commonly suggests poor prognosis. It has anti-apoptotic as well as proliferative effects.The Stat3 protein is transcription factor expressed in most cell types and is activated by multiple cytokines and growth factors including: IFN-a, IL-10, IL-6, IL-11, IL-12, IL-2, EGF etc. Stat3 binds to DNA as either a homodimer or as a heterodimer with Stat1. Stat3 interacts with the APRE (acute phase response element) & SIE (c-sis inducible element).
Product Description: STAT3 Human Recombinant encoding aa 50-240 expressed in E.coli, shows a 49kDa band on SDS-PAGE (including GST tag).The STAT3 is purified by proprietary chromatographic techniques.