Anti- STAT3 (Phospho-Ser727) Antibody (GWB-206930)

GWB-206930

18-785-210427

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Description

Binding Site: Ser727 WB Dilution: 500~1000

IHC Dilution: 50~100 Function: Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

Subunit: Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with NCOA1, PELP1, SOCS7 and STATIP1. Interacts with HCV core protein. Interacts with IL23R in presence of IL23. Interacts with IL31RA.

Subcellular Location: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.

Tissue Specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Ptm: Tyrosine phosphorylated in response to IL-6, IL-11, CNTF, LIF, CSF-1, EGF, PDGF, IFN-alpha and OSM. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity.

Miscellaneous: Involved in the gp130-mediated signaling pathway.

Similarity: Belongs to the transcription factor STAT family.

Similarity: Contains 1 SH2 domain. [1] Akira S., Nishio Y., Inoue M., Wang X.-J., Wei S., Matsusaka T., Yoshida K., Sudo T., Naruto M., Kishimoto T., et al.
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.
[2] Della Pietra L., Bressan A., Pezzotti A., Serlupi-Crescenzi O.
Highly conserved amino-acid sequence between murine STAT3 and a revised human STAT3 sequence.
[3] Rieder M.J., Daniels R.L., da Ponte S.H., Hastings N.C., Ahearn M.O., Rajkumar N., Yi Q., Nickerson D.A.
SeattleSNPs. NHLBI HL66682 program for genomic applications, UW-FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu).
[4] Della Pietra L., Bressan A., Pezzotti A.R., Serlupi-Crescenzi O.
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
[5] Zhang X., Blenis J., Li H.-C., Schindler C., Chen-Kiang S.
Requirement of serine phosphorylation for formation of STAT-promoter complexes.
[6] Giraud S., Bienvenu F., Avril S., Gascan H., Heery D.M., Coqueret O.
Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.
[7] Yoshida T., Hanada T., Tokuhisa T., Kosai K., Sata M., Kohara M., Yoshimura A.
Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation.
[8] Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K.P., Vega F., et al.
A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.
[9] Dreuw A., Radtke S., Pflanz S., Lippok B.E., Heinrich P.C., Hermanns H.M.
Characterization of the signaling capacities of the novel gp130-like cytokine receptor.
[10] Manavathi B., Nair S.S., Wang R.-A., Kumar R., Vadlamudi R.K.
Proline-, glutamic acid-, and leucine-rich protein-1 is essential in growth factor regulation of signal transducers and activators of transcription 3 activation.

Additional Information

Name Anti- STAT3 (Phospho-Ser727) Antibody (GWB-206930)
Availability In Stock
Related Product Names Acute-phase response factor APRFSTAT3 (Phospho-Ser727)STAT-3
Swissprot ID P40763
Molecular Weight 88068
Purity Affinity Purified
Source Rabbit
Application IHC, WB
Clonality Polyclonal
Format In PBS, 0.02% sodium azide and 50% glycerol.
Stability 1 year at -20C
Reactivity Human, Mouse, Rat
Storage 4C for short term (weeks) and -20C for long term. Avoid frequent freeze and thaw.
Datasheets/Manuals Printable datasheet for GWB-206930
Intended Use Research Use Only