STAT3 (Phospho-Ser727) Antibody Blocking Peptide (GWB-1DCC31)



0.1 mg
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Function: Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.

Subunit: Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with NCOA1, PELP1, SOCS7 and STATIP1. Interacts with HCV core protein. Interacts with IL23R in presence of IL23. Interacts with IL31RA. Interacts with SIPAR (By similarity).

Subcellular Location: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.

Tissue Specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Ptm: Tyrosine phosphorylated in response to IL-6, IL-11, CNTF, LIF, CSF-1, EGF, PDGF, IFN-alpha and OSM. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity.

Disease: Defects in STAT3 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal dominant (AD-HIES) [MIM:147060]; also known as hyper-IgE syndrome or Job syndrome. AD-HIES is a rare disorder of immunity and connective tissue characterized by immunodeficiency, chronic eczema, recurrent Staphylococcal infections, increased serum IgE, eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures.

Miscellaneous: Involved in the gp130-mediated signaling pathway.

Similarity: Belongs to the transcription factor STAT family.

Similarity: Contains 1 SH2 domain.

Additional Information

Name STAT3 (Phospho-Ser727) Antibody Blocking Peptide (GWB-1DCC31)
Related Product Names Acute-phase response factor APRFSTAT3 (Phospho-Ser727) Antibody Blocking PeptideSTAT3
Swissprot ID P40763
NCBI Acc Number NP_003141.2
Molecular Weight 88068
Datasheets/Manuals Printable datasheet for GWB-1DCC31
Intended Use Research Use Only