RECOMBINANT HUMAN TNF ALPHA (GWB-10B349)

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GWB-10B349

10-783-79199

0.01 mg
$273.00

Description

Summary: This protein is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq].

Additional Information

Name RECOMBINANT HUMAN TNF ALPHA (GWB-10B349)
Related Product Names RECOMBINANT HUMAN TNF ALPHA
Description of Target RECOMBINANT HUMAN TNF ALPHA
Gene Symbol TNF
Gene Family TNFSF
Gene id 7124
Alias Symbols DIF, TNFA, TNFSF2, TNF-alpha, TNF
Swissprot ID P01375
Protein Name Tumor necrosis factor
Protein Accession Num NP_000585.2
Homology Human
NCBI Acc Number NP_000585.2
Product Format Purified recombinant protein - lyophilised
Molecular Weight 17.5 kD (157 amino acids)
Purity SDS PAGE: >97%
Application ELISA
GI Number 25952111
Format Purified recombinant protein - lyophilised
Reconstitution and Storage Reconstitution: Reconstitute in sterile DI water to 0.1 mg/ml for storage and further dilution.
Storage: Prior to reconstitution store at +4oC.
After reconstitution store at -20oC.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein.
Reactivity Human
Sequence Length 233
Storage Store with a desiccant at -20C.
Datasheets/Manuals Printable datasheet for GWB-10B349
Species Reactivity Human
Intended Use Research Use Only
Additional Information Activity: Approximately 2x10(e)7 units/mg. This was determined by cytolysis of murine cells in the presence of actinomycin-D.
:: Endotoxin Level: < 0.1 ng/ ug
:: Label Protein Molar Ratio: Expressed in E. coli
Preservative: None present