TNF BETA (GWB-77DC6D)

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GWB-77DC6D

10-783-79037

0.02 mg
$452.00

Description

Summary: This protein is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq].

Additional Information

Name TNF BETA (GWB-77DC6D)
Related Product Names RECOMBINANT HUMAN TNF BETA TNF BETA
Description of Target RECOMBINANT HUMAN TNF BETA
Gene Symbol LTA
Gene Family TNFSF
Gene id 4049
Alias Symbols LT, TNFB, TNFSF1, LTA
Swissprot ID P01374
Protein Name Lymphotoxin-alpha
Protein Accession Num NP_000586.2
Homology Human
NCBI Acc Number NP_000585.2
Product Format Purified recombinant protein - lyophilised
Molecular Weight 18.6kD (172 amino acid sequence)
Specificity Tumour necrosis factor beta (TNFbeta) is a lymphoid factor which exerts cytotoxic effects on a wide range of tumour cells.
Purity >98% by SDS PAGE and HPLC analysis
Application CA
GI Number 25952111
Format Rec. Protein
Stability 3 months from date of reconstitution.
Reconstitution and Storage Reconstitution: Reconstitute with 20 ul distilled water
Storage: Prior to reconstitution store at +4oC. Following reconstitution store at -20oC.
This product should be stored undiluted.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Reactivity Human
Application Info Cytotoxic Assays:    0.05ng/ml - 10ng/ml
Storage Prior to reconstitution store at +4 degree C. Following reconstitution store at -20 degree C.
This product should be stored undiluted.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the pr
Datasheets/Manuals Printable datasheet for GWB-77DC6D
Species Reactivity Human
Intended Use Research Use Only
Additional Information Activity: >2 x 107 units/mg
Approx Protein Conc: 1.0 mg/ml after reconstitution
Buffer solution: Phosphate buffered saline
:: Endotoxin Level: < 0.1 ng/ug of TNF-beta (< 1 EU/ug)
:: Label Protein Molar Ratio: Recombinant protein prepared in Escherichia coli
Preservative: None present