Human CD120b Protein (GWB-B2A64C)

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20 µg
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Additional Information

Name Human CD120b Protein (GWB-B2A64C)
Description of Target RECOMBINANT HUMAN CD120b
Gene Symbol TNFRSF1B
Gene Family CD
Gene id 7133
Alias Symbols p75, TBPII, TNFBR, TNFR2, CD120b, TNFR1B, TNFR80, TNF-R75, p75TNFR, TNF-R-II, TNFRSF1B
Swissprot ID P20333
Protein Name Tumor necrosis factor receptor superfamily member 1B
Protein Accession Num NP_001057.1
Homology Human
Product Format Purified recombinant protein - lyophilised
Molecular Weight 18.9kD (174 amino acid residues)_x000D_
Specificity The soluble form of human CD120b, otherwise known as sTNF receptor type II (sTNFRII), is a member of the tumour necrosis factor receptor (TNFR) superfamily, produced by proteolytic cleavage of the membrane form by the metalloprotease TACE.
CD120b plays a key role in regulating the inflammatory response, acting as a receptor for both tumour necrosis factor alpha (TNF-alpha) and TNF-beta, and is also involved in programmed cell death and anti-viral activity. sTNFRII acts as an inhibitor of TNF-alpha induced responses, by acting as a decoy receptor.
Purity >98% by SDS PAGE and HPLC analysis_x000D_
Application FN
Format Purified recombinant protein - lyophilised
Stability 3 months from date of reconstitution.
Reconstitution and Storage Reconstitution: Reconstitute with 200ul distilled water
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Aviva Systems Biology recommend that the vial is gently mixed after reconstitution.
Reactivity Human
Storage Prior to reconstitution store at +4oC.
After reconstitution store at -20oC.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature th
Datasheets/Manuals Printable datasheet for GWB-B2A64C
Species Reactivity Human
Intended Use Research Use Only
Additional Information Activity: Determined by its inhibitory effect of the TNF-alpha mediated cytotoxicity in murine L-929 cells. The ED50 for this effect in the presence of 0.25 ng/ml of recombinant human TNF-alpha is 0.125 ug/ml.
Approx Protein Conc: 0.1mg/ml
:: Endotoxin Level: < 1EU/ug
:: Label Protein Molar Ratio: Purified recombinant CD120b expressed in E.coli
Preservative: None present