P27 kip1 protein (GWB-342D31)



1 mg


Fusion: His-Tag at N-terminus. Summary: This protein is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [1] Markaki,E.A., Stiakaki,E., Zafiropoulos,A., Arvanitis,D.A., Katzilakis,N., Dimitriou,H., Spandidos,D.A. and Kalmanti,M.
Mutational analysis of the cell cycle inhibitor Kip1/p27 in childhood leukemia
[2] Bryant,P., Zheng,Q. and Pumiglia,K., et al.
Focal adhesion kinase controls cellular levels of p27/Kip1 and p21/Cip1 through Skp2-dependent and -independent mechanisms
[3] Taube,M.E., Liu,X.W., Fridman,R. and Kim,H.R., et al.
TIMP-1 regulation of cell cycle in human breast epithelial cells via stabilization of p27(KIP1) protein
[4] Zannoni,G.F., Faraglia,B., Tarquini,E., Camerini,A., Vrijens,K., Migaldi,M., Cittadini,A. and Sgambato,A.
Expression of the CDK inhibitor p27kip1 and oxidative DNA damage in non-neoplastic and neoplastic vulvar epithelial lesions
[5] Kase,S., Yoshida,K., Ohgami,K., Shiratori,K., Suzuki,Y., Nakayama,K.I. and Ohno,S.
Expression of cdc2 and p27(KIP1) phosphorylation in mitotic cells of the human retinoblastoma
[6] , Ferrando A.A., Balbin M., Pendas A.M., Vizoso F., Velasco G., Lopez-Otin C.
Mutational analysis of the human cyclin-dependent kinase inhibitor p27kip1 in primary breast carcinomas.

Additional Information

Name P27 kip1 protein (GWB-342D31)
Related Product Names KIP1; CDKN4; P27KIP1P27 kip1 proteinp27 kip1
Swissprot ID O43806
NCBI Acc Number NP_004055.1
Molecular Weight 17651
Purity 90%
Source E Coli
Application MS, SDS
GI Number 4757962
Format 10 mM Tris, pH 8.0, 0.05% Tween 20.
Stability 6-12 months at -70 degree C.
Reactivity human
Sequence Length 198
Chrom Location 12p13.1-p12
Datasheets/Manuals Printable datasheet for GWB-342D31
Storage -70 degree C. Avoid frequent freeze and thaw.
Intended Use Research Use Only