p57/ KIP2 Antibody (GWB-B758A7)



0.1 ml


Clone ID: EP2516

Immunogen: A synthetic peptide corresponding to residue within the internal region of human p57/ KIP2 was used as an immunogen. Specificity: A synthetic peptide corresponding to residue within the internal region of human p57/KIP2 was used as an immunogen. Dilution: WB: 1:1,000 - 10,000. p57/ KIP2 is a potent, tight-binding inhibitor of several G1 cyclin/Cdk complexes, and its binding is cyclin dependent. Its over-expression leads to arrest of cell in G1 phase. Human p57/ KIP2 appears to have conserved the amino- and carboxy-terminal domains but has replaced the internal regions with sequences containing proline-alanine repeats. Expression patterns suggest a complex role for p57 /KIP2 cell cycle control and development (1). The gene encoding p57/ KIP2 is located at a region implicated in both sporadic cancers and Beckwith-Wiedemann syndrome (BWS). Nonsense mutation found in the Cdk inhibitory domain in a BWS patient rendered p57/ KIP2 inactive with consequent complete loss of its role as a cell cycle inhibitor and of its nuclear localization. Additionally, the mutation in the QT domain, although completely retaining its cell cycle regulatory activity, lacked nuclear localization and was thus prevented from performing its role as an active cell cycle inhibitor. (2). Mice lacking the imprinted Cdk inhibitor p57/ KIP2 have altered cell proliferation and differentiation, leading to abdominal muscle defects; cleft palate; endochondral bone ossification defects with incomplete differentiation of hypertrophic chondrocytes (3). 1. Manufactured under U.S. Patents, No. 5,675,063 and 7,429,487

Additional Information

Name p57/ KIP2 Antibody (GWB-B758A7)
Related Product Names p57/ KIP2 Rabbit Monoclonal Antibody p57/ KIP2
Swissprot ID P49918
Molecular Weight 57 kDa
Source Rabbit
Application WB
Clonality Monoclonal
Reactivity Human
Datasheets/Manuals Printable datasheet for GWB-B758A7
Storage Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Intended Use Research Use Only