RABBIT ANTI HUMAN PLK1 Antibody (GWB-78C0A7)

This exact product is now provided by Aviva Systems Biology.
Please visit OASA08116 to review further and for ordering information.


GWB-78C0A7

18-783-313924

#N/A
$0.00

Description

Function: Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS. Ref.8Ref.10Ref.15Ref.19Ref.20Ref.23Ref.27Ref.29Ref.30Ref.36

Additional Information

Name RABBIT ANTI HUMAN PLK1 Antibody (GWB-78C0A7)
Related Product Names PLKRABBIT ANTI HUMAN PLK1PLK1
Gene Symbol PLK1
Gene id 5347
Alias Symbols PLK, STPK13, PLK1
Swissprot ID P53350
Protein Name Serine/threonine-protein kinase PLK1
Description of Target RABBIT ANTI HUMAN PLK1
Protein Accession Num NP_005021.2
Application Info Immunohistology - Paraffin:    10ug/ml
ELISA:    1:200 - 1:2000
Western Blotting:    1:3000 - 1:12000
Host Rabbit
Immunogen The immunogen for anti-PLK1 antibody: a synthetic peptide sequence corresponding to aa 205 - 214 of human PLK1
Isotype Polyclonal IgG
Homology Human
Product Format Purified IgG - liquid
Specificity PLK1
Application E, P, WB
Clonality Polyclonal Antibody
Format Purified IgG - liquid
Stability 18 months from date of despatch.
Reconstitution and Storage Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Reactivity Human
Datasheets/Manuals Printable datasheet for GWB-78C0A7
Storage Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product cont
Species Reactivity Human
Lead Time Domestic: within 2-3 weeks delivery | International: 2-3 weeks
Intended Use Research Use Only
Additional Information Histology Positive Control Tissue: Human uterus
:: Preservative Stabilisers: 0.01% Sodium Azide (NaN3)
Antiserum Preparation: Antisera to Human PLK1 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
:: Approx Protein Conc: IgG concentration 2.0mg/ml
Buffer Solutions: Phosphate buffered saline pH7.2