Recombinant Human S-Phase Kinase-Associated Protein 2 (GWB-5A131D)

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GWB-5A131D

10-663-46623

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$0.00

Description

Short Description: Introduction SKP2 enzyme is a substrate recognition component of the SCF E3 ubiquitin ligase complex which is involved in the ubiquitination and subsequent proteasomal degradation of target proteins which take part in cell cycle progression, signal transduction and transcription. SKP2 specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SKP2 gene is recognized as a protooncogene regularly involved in the pathogenesis of lymphomas. SKP2 is part of the F-box protein family which is known for its 40 amino acid motif, the F-box. F-box proteins comprise 1 of the 4 subunits of ubiquitin protein ligase complex called SCFs, which play a role in phosphorylation-dependent ubiquitination. There are 3 F-box classes Fbws having WD-40 domains, Fbls having leucine-rich replicates, and Fbxs having either diverse protein-protein interaction or no recognizable motifs. SKP2 is part of the Fbls class.Description SKP2 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 205 amino acids (221-425 a.a.) fused to a GST tag and having a total molecular mass of 49kDa. The SKP2 is purified by proprietary chromatographic techniques.

Additional Information

Name Recombinant Human S-Phase Kinase-Associated Protein 2 (GWB-5A131D)
Related Product Names SKP2, S-Phase Kinase-Associated Protein 2 Recombinant, S-phase kinase-associated protein 2,F-box protein Skp2, Cyclin A/CDK2-associated protein p45, p45skp2, F-box/LRR-repeat protein 1, SKP2, FBL1, FBXL1, FLB1, MGC1366 Recombinant Human S-Phase Kinase-Ass
Gene Symbol SKP2
Gene Family FBXL
Gene id 6502
Alias Symbols S-phase kinase-associated protein 2, F-box protein Skp2, Cyclin A/CDK2-associated protein p45, p45skp2, F-box/LRR-repeat protein 1, SKP2, FBL1, FBXL1, FLB1, MGC1366, SKP2 Human, S-Phase Kinase-Associated Protein 2 Human Recombinant
Swissprot ID Q13309
Protein Name S-phase kinase-associated protein 2
Description of Target Recombinant Human S-Phase Kinase-Associated Protein 2
Protein Accession Num NP_005974.2
Host E. Coli
Product Format SKP2 is supplied in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol. Physical appearance: Sterile Filtered clear solution.
Format SKP2 is supplied in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol.
Reconstitution and Storage Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. Please avoid freeze thaw cycles.
Datasheets/Manuals Printable datasheet for GWB-5A131D
Storage Store at 4C if entire vial will be used within 2-4 weeks. Store frozen at -20C for longer periods of time. Please avoid freeze thaw cycles.
Lead Time Domestic: within 1-2 weeks delivery | International: 1-2 weeks
Intended Use Research Use Only
:: Product Introduction: SKP2 enzyme is a substrate recognition component of the SCF E3 ubiquitin ligase complex which is involved in the ubiquitination and subsequent proteasomal degradation of target proteins which take part in cell cycle progression, signal transduction and transcription. SKP2 specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SKP2 gene is recognized as a protooncogene regularly involved in the pathogenesis of lymphomas. SKP2 is part of the F-box protein family which is known for its 40 amino acid motif, the F-box. F-box proteins comprise 1 of the 4 subunits of ubiquitin protein ligase complex called SCFs, which play a role in phosphorylation-dependent ubiquitination. There are 3 F-box classes: Fbws having WD-40 domains, Fbls having leucine-rich replicates, and Fbxs having either diverse protein-protein interaction or no recognizable motifs. SKP2 is part of the Fbls class.
Product Description: SKP2 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 205 amino acids (221-425 a.a.) fused to a GST tag and having a total molecular mass of 49kDa. The SKP2 is purified by proprietary chromatographic techniques.