Interleukin-2: Human Recombinant E Coli (GWB-8A10A7)



1 mg


Interkeukin-2 is a pleiotropic cytokine produced primarily by mitogenic or antigen activated T lymphocytes. IL-2 plays a key role in T cell proliferation and promotes the proliferation, expansion and differentiation of a wide variety of antigen specific cells.
RANDOX recombinant Interleukin-2 comprises a 133amino acid fragment (21-153) corresponding to the mature Interleukin-2 protein and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic ortherapeutic use.

Function: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

Subcellular Location: Secreted.

Disease: A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

Pharmaceutical: Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma.

Similarity: Belongs to the IL-2 family. 1: Fletcher, M. & Goldstein, A.L. (1987) Lymphokine Res.6(1): 45- 57.
Jelinek, D.F. et al., (1986) Eur. J. Immunol. 16(8): 925- 932.

Additional Information

Name Interleukin-2: Human Recombinant E Coli (GWB-8A10A7)
Related Product Names IL-2; T-Cell Growth Factor; TCGF.; IL-2; T-cell growth factor; TCGF; Aldesleukin Interleukin-2: Human, Recombinant, E ColiIL2
Swissprot ID P60568
NCBI Acc Number NP_000577.2
Molecular Weight 17628
Purity >95% by SDS-PAGE
Source E Coli
Application SDS-Page
Format Liquid
Datasheets/Manuals Printable datasheet for GWB-8A10A7
Intended Use Research Use Only