PI3-kinase p110 subunit delta Antibody (GWB-28DA26)

GWB-28DA26

20-203-420205

0.1 ml
$294.00

Description

Clone ID: Y387

Immunogen: A synthetic peptide of human PI3-K p110 delta was used as an immunogen. Specificity: A synthetic peptide of human PI3-K p110 delta was used as an immunogen. Dilution: WB: 1:500
ICC: 1:250-500
IP: 1:50. PI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signal transduction. PI3-K consists of two subunits; p85 and p10. The p85 subunit localize PI3-K activity to the plasma membrane while the p110 subunit contains the catalytic domain of PI3-K (1-2). Four isoforms of p110 has been found; the a, beta, , and the subunit (3). The delta isoform is predominantly expressed in leukocytes and has been shown to interact with p85 and GTP-bound Ras via its SH2/SH3 domain (4). 1. Jaiswal BS, Janakiraman V, Kljavin NM, et al, PI3-kinase p110 subunit delta ,Cancer Cell 16 (2009) 463-474
[Application: WB]
2. Pang H, Flinn R, Patsialou A, et al, PI3-kinase p110 subunit delta ,Cancer Res 69 (2009) 8868-8876
3. Pang H, Flinn R, Patsialou A, et al, Differential Enhancement of Breast Cancer Cell Motility and Metastasis by Helical and Kinase Domain Mutations of Class IA Phosphoinositide 3-Kinase ,Cancer Res 69 (2009) 8868-8876
[Application: WB]
1. Otsu, M., Hiles, I. D., Gout, I., Fry, M. J., Ruiz-Larrea, F., Panayatou, G., Thompson, A., Dhand, R., Hsuan, J., Totty, N., Smith, A. D., Morgan, S. J., Courtnidge, S. A., Parker, P. J., and Waterfield, M. D. (1992) Cell 65, 91-104
2. Hiles, I. D., Otsu, M., Volinia, S., Fry, M. J., Gout, I., Dhand, R., Panayatou, G., Ruiz-Larrea, F., Thompson, A., Totty, N. F., Hsuan, J. J., Courtnidge, S. A., Parker, P. J., and Waterfield, M. D. (1991) Cell 70, 419-429
3. Hu, P., Mondino, A., Skolnik, E. Y., and Schlessinger, J. (1993) Mol. Cell. Biol. 13, 7677-7688
4. Rodriguez-Viciana, P., Warne, P. H., Vanhaesebroeck, B., Waterfield, M. D. & Downward, J. (1996) EMBO J. 15, 2442-2451
5. Manufactured under U.S. Patents, No. 5,675,063 and 7,429,487

Additional Information

Name PI3-kinase p110 subunit delta Antibody (GWB-28DA26)
Availability Discontinued
Related Product Names PI3-kinase p110 subunit delta Rabbit Monoclonal Antibody PIK3CD, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform, p110deltaPI3-kinase p110 subunit delta
Swissprot ID O00329
Molecular Weight 110 kDa
Source Rabbit
Application WB, ICC, IP
Clonality Monoclonal
Reactivity Human
Storage Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Datasheets/Manuals Printable datasheet for GWB-28DA26
Intended Use Research Use Only