PI3-kinase p110 subunit gamma N-term Antibody (GWB-6214E2)

GWB-6214E2

20-203-420231

0.1 ml
$294.00

Description

Clone ID: Y388

Immunogen: A synthetic peptide of in the N-term of human PI3-K p110 gamma was used as an immunogen. Specificity: A synthetic peptide of in the N-term of human PI3-K p110 gamma was used as an immunogen. Dilution: WB: 1:1,000
FC: 1:50
IP: 1:50. PI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signal transduction. PI3-K consists of two subunits; p85 and p10. The p85 subunit localize PI3-K activity to the plasma membrane while the p110 subunit contains the catalytic domain of PI3-K (1-2). Four isoforms of p110 has been found; a, beta, and the subunit (3). The gamma isoform is most clostly related to p110 a, and beta and has been shown not to interact with p85 in vivo (4). It has been found that in p110-gamma protein expression is lost in primary colorectal adeno-carcinomas and in colon cancer cell lines (5) 1. Otsu, M., Hiles, I. D., Gout, I., Fry, M. J., Ruiz-Larrea, F., Panayatou, G., Thompson, A., Dhand, R., Hsuan, J., Totty, N., Smith, A. D., Morgan, S. J., Courtnidge, S. A., Parker, P. J., and Waterfield, M. D. (1992) Cell 65, 91-104
2. Hiles, I. D., Otsu, M., Volinia, S., Fry, M. J., Gout, I., Dhand, R., Panayatou, G., Ruiz-Larrea, F., Thompson, A., Totty, N. F., Hsuan, J. J., Courtnidge, S. A., Parker, P. J., and Waterfield, M. D. (1991) Cell 70, 419-429
3. Hu, P., Mondino, A., Skolnik, E. Y., and Schlessinger, J. (1993) Mol. Cell. Biol. 13, 7677-7688
4. Stoyanov et al. Science 269: 690-693, 1995
5. Sasaki et al. Nature 406: 897-902, 2000.
6. Manufactured under U.S. Patents, No. 5,675,063 and 7,429,487

Additional Information

Name PI3-kinase p110 subunit gamma N-term Antibody (GWB-6214E2)
Related Product Names PI3-kinase p110 subunit gamma, N-term Rabbit Monoclonal Antibody PIK3CG, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, p120-PI3KPI3-kinase p110 subunit gamma, N-term
Swissprot ID P48736
Molecular Weight 110 kDa
Source Rabbit
Application WB, FC, IP
Clonality Monoclonal
Reactivity Human
Storage Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Datasheets/Manuals Printable datasheet for GWB-6214E2
Intended Use Research Use Only