CD95 Protein His (GWB-1FAB7A)

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GWB-1FAB7A

10-663-46665

5ug
$69.00
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Description

Short Description: Introduction FAS / CD95 is a 36kDa transmembrane type I receptor, which belongs to the NF/NGF receptor super-family. It is a potent inducer of apoptosis in cells of the immune system upon interaction with its natural ligand, CD95L. Although the CD95/CD95L system could play a role in tumor regression, tumor cells seem to down-regulate CD95 expression as a mechanism of resistance to CD95L-induced killing by T lymphocytes and NK cells. The Fas antigen is expressed on the surface of various cell types, including activated T and B lymphocytes and T lymphoblastoid cell line. CD95 is also expressed in a broad panel of non-transformed cells outside the immune system.Description Recombinant FAS antigen/ CD95 purified from E. coli is a single non-glycosilated polypeptide chain containing amino acids 157-320 of Fas antigen (base pairs 713-1190 of cDNA sequence). The recombinant CD95 is fused to C-terminal 6-histidine amino acids.The FAS antigen is purified by proprietary chromatographic techniques.

Additional Information

Name CD95 Protein His (GWB-1FAB7A)
Related Product Names CD95 His, CD95 Recombinant, His Tag, CD95, CD-95, Tumor necrosis factor receptor superfamily member 6, FASLG receptor, Apoptosis-mediating surface antigen FAS, Apo-1 antigen, CD95 antigen, FAS, APT1, FAS1, TNFRSF6, APO-1, FASTM, ALPS1A Recombinant Human C
Gene Symbol CD95 His
Gene id 355
Alias Symbols CD95, CD-95, Tumor necrosis factor receptor superfamily member 6, FASLG receptor, Apoptosis-mediating surface antigen FAS, Apo-1 antigen, CD95 antigen, FAS, APT1, FAS1, TNFRSF6, APO-1, FASTM, ALPS1A, CD95 Human His, CD95 Human Recombinant,
Swissprot ID P25445
Protein Name Tumor necrosis factor receptor superfamily member 6
Description of Target Recombinant Human CD95, His Tag
Protein Accession Num NP_000034.1
Host E. Coli
Product Format 8M urea, 20mM Tris-HCl, pH-8.0, 0.2M Imidazole, 0.01M b-ME. Physical appearance: Sterile liquid formulation.
Purity Greater than 95% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Format 8M urea, 20mM Tris-HCl, pH-8.0, 0.2M Imidazole, 0.01M b-ME.
Reconstitution and Storage CD95 although stable at 10C for 5 days, should be stored desiccated below -18C. Please prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for GWB-1FAB7A
Storage CD95 although stable at 10 C for 5 days, should be stored desiccated below -18 C.Please prevent freeze-thaw cycles.
Lead Time Domestic: within 1-2 weeks delivery | International: 1-2 weeks
Intended Use Research Use Only
:: Product Introduction: FAS / CD95 is a 36kDa transmembrane type I receptor, which belongs to the NF/NGF receptor super-family. It is a potent inducer of apoptosis in cells of the immune system upon interaction with its natural ligand, CD95L. Although the CD95/CD95L system could play a role in tumor regression, tumor cells seem to down-regulate CD95 expression as a mechanism of resistance to CD95L-induced killing by T lymphocytes and NK cells. The Fas antigen is expressed on the surface of various cell types, including activated T and B lymphocytes and T lymphoblastoid cell line. CD95 is also expressed in a broad panel of non-transformed cells outside the immune system.
Product Description: Recombinant FAS antigen/ CD95 purified from E. coli is a single non-glycosilated polypeptide chain containing amino acids 157-320 of Fas antigen (base pairs 713-1190 of cDNA sequence). The recombinant CD95 is fused to C-terminal 6-histidine amino acids.The FAS antigen is purified by proprietary chromatographic techniques.