CHMP2A Protein (GWB-355975)

GWB-355975

10-663-46164

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Description

Similarity: Contains 3 TNFR-Cys repeats.

Function: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

Additional Information

Name CHMP2A Protein (GWB-355975)
Related Product Names CD-95 Human Recombinant; FASLG receptor; Apoptosis-mediating surface antigen FAS; Apo-1 antigen; CD95 antigen APT1; FAS1; TNFRSF6CD95 HumanFAS
Gene Symbol CHMP2A
Gene Family CHMP
Gene id 27243
Alias Symbols Charged multivesicular body protein 2a, Chromatin-modifying protein 2a, Vacuolar protein-sorting-associated protein 2-1, Putative breast adenocarcinoma marker BC-2, Vps2-1, hVps2-1, CHMP2A, BC2, CHMP2, BC-2, VPS2, VPS2A, CHMP2A Human, Chromat
Swissprot ID O43633
Protein Name Charged multivesicular body protein 2a
Description of Target Recombinant Human Chromatin Modifying Protein 2A
Protein Accession Num NP_055268.1
Host E. Coli
Peptide Sequence MGSSHHHHHH SSGLVPRGSH MDLLFGRRKT PEELLRQNQR ALNRAMRELD RERQKLETQE KKIIADIKKM AKQGQMDAVR IMAKDLVRTR RYVRKFVLMR ANIQAVSLKI QTLKSNNSMA QAMKGVTKAM GTMNRQLKLP QIQKIMMEFE RQAEIMDMKE EMMNDAIDDA MGDEEDEEES DAVVSQVLDE LGLSLTDELS NLPSTGGSLS VAAGGKKAEA AASALADADA DLEERLKNLR RD.
Product Format The CHMP2A solution contains 20mM Tris-HCl buffer (pH8.0), 0.1M NaCl 1mM DTT, and 30% glycerol. Physical appearance: Sterile Filtered colorless solution.
Purity Greater than 90.0% as determined by SDS-PAGE.
Reconstitution and Storage CHMP2A although stable 4C for 4 weeks, should be stored desiccated below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for GWB-355975
Intended Use Research Use Only
:: Product Introduction: Chromatin modifying protein 2A (CHMP2A) is a member of the SNF7 family and it is a component of the ESCRT III complex, which is required for MVBs (multivesicular bodies) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates release of transmembrane proteins into the lumen of the lysosome for degradation. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins generally detach from the invaginating membrane before the ILV (intraluminal vesicles) is released. ESCRT-III proteins are thought to mediate the basic vesicle extrusion and/or membrane fission activities, probably in conjunction with the AAA ATPase VPS4.
Product Description: CHMP2A Human Recombinant fused with 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 242 amino acids (1-222 a.a.) and having a molecular mass of 27.2 kDa.The CHMP2A is purified by proprietary chromatographic techniques.