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CSTA Protein (GWB-1D122F)

GWB-1D122F

10-663-46200

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Description

Similarity: Belongs to the cystatin family.

Function: This is an intracellular thiol proteinase inhibitor.

Additional Information

Name CSTA Protein (GWB-1D122F)
Related Product Names Stefin A Human Recombinant; Cystatin-AS; Stefin-A STF1; STFAStefin-A HumanCSTA
Drywet Surcharge 0
Gene Symbol Cystatin-A
Gene id 1475
Alias Symbols Cystatin-A, Cystatin-AS, Stefin-A, CSTA, STF1, STFA, Cystatin A Human, Cystatin A Human Recombinant
Protein Name Cystatin-A
Description of Target Recombinant Human Cystatin-A
Swissprot ID P01040
Protein Accession Num NP_005204.1
Host E. Coli
NCBI Acc Number NP_005204.1
Product Format Cystatin-A in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol. Physical appearance: Sterile Filtered clear solution.
Datasheets / Downloads GWB-1D122F Datasheet
Swiss Prot Number P01040
Reconstitution and Storage Store vial at -20C to -80C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.
Intended Use Research Use Only
:: Product Introduction: Cystatin-A is the intracellular inhibitor of cysteine proteinase cathepsin B (CatB) and belongs to family 1 of the cystatin superfamily of inhibitor proteins. CSTA is a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. It has been proposed that extracellular CatB together with other classes of proteinases are all subjected to a cascade-like manner of activation. CatB and its inhibitor Cystatin-A are involved in degradation of extracellular matrix proteins during tissue remodeling. CSTA is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Cystatin-A has been reported to be found in high concentrations in epithelial cells, polymorphonuclear leukocytes and lymphoid tissue. Stefins may be used as prognostic and diagnostic tools for cancer.
Product Description: Cystatin-A Human Recombinant full length protein expressed in E.coli, shows a 37 kDa band on SDS-PAGE (including GST tag).The Cystatin-A is purified by proprietary chromatographic techniques.