Fas-activated serine/threonine kinase (GWB-4030BA)



1 mg


Fusion: T7 tag at N-terminus. Function: Fas-mediated apoptosis is characterized by FASTK-dephosphorylation and TIA-1-phosphorylation. Both are activated and FASTK-mediated TIA-1 activation play a key role in apoptosis.

Catalytic Activity: ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein].

Subunit: Interacts with TIA-1.

Tissue Specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Ptm: Phosphorylated on serine/threonine.

Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [1] Li,W., Simarro,M., Kedersha,N. and Anderson,P., et al.
FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression
[2] Scherer,S.W., Cheung,J., MacDonald,J.R., Osborne,L.R., Nakabayashi,K., Herbrick,J.A., Carson,A.R., Parker-Katiraee,L.,, et al.
Human chromosome 7: DNA sequence and biology
[3] Suzuki,Y., Yoshitomo-Nakagawa,K., Maruyama,K., Suyama,A. and Sugano,S.
Construction and characterization of a full length-enriched and a 5\'-end-enriched cDNA library
[4] Tian,Q., Taupin,J., Elledge,S., Robertson,M. and Anderson,P., et al.
Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis
[5] Auffray,C., Behar,G., Bois,F., Bouchier,C., Da Silva,C., Devignes,M.D., Duprat,S., Houlgatte,R., Jumeau,M.N., Lamy,B. et al.
[IMAGE: molecular integration of the analysis of the human genome and its expression]
[6] , Tian Q., Taupin J.-L., Elledge S., Robertson M., Anderson P.
Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.
[7] , Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.

Additional Information

Name Fas-activated serine/threonine kinase (GWB-4030BA)
Related Product Names EC; FAST kinase FASTFas-activated serine/threonine kinaseFASTK
Swissprot ID Q14296
NCBI Acc Number NP_006703.1
Molecular Weight 61104
Purity 95%
Source E Coli
Application MS, SDS
GI Number 5729822
Format 10 mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% NaN3, 10mM DTT.
Stability 6-12 months at -70 degree C.
Reactivity human
Sequence Length 549
Chrom Location 7q35
Datasheets/Manuals Printable datasheet for GWB-4030BA
Storage -70 degree C. Avoid frequent freeze and thaw.
Intended Use Research Use Only