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MAP2K2 Antibody

GWB-1E67A0

20-614-460459

0.1 ml
$493.20
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Description

Immunogen: Protein expressed in 293T cell transfected with human MAP2K2 expression vector. Clone Name: clone 8G6

Isotype: IgG1 Description: Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2)

Concentration: 0.9 mg/ml

Suggested Dilutions: WB 1:2000 IHC 1:50 The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases.Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Additional Information

Name MAP2K2 Antibody
Related Product Names FLJ26075; MAPKK2; MEK2; MKK2; PRKMK2MAP2K2 AntibodyMAP2K2
NCBI Acc Number NM_030662
Purity Purified MAP2K2 mouse monoclonal antibody, clone 8G6
Source Mouse
Applications WB, IHC
Clonality Monoclonal
Format PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Reactivity Human
Datasheets/Manuals Printable datasheet for GWB-1E67A0
Intended Use Research Use Only