GDF15 Protein (GWB-1F9A4A)

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GWB-1F9A4A

10-663-46901

2ug
$69.00
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Description

Sequence: Xiang,Z., Morse,E., Hu,X.L., Flint,J., Chi,H.C., Grady,D.L., Moyzis,R.K. and Riethman,H.C.

Additional Information

Name GDF15 Protein (GWB-1F9A4A)
Related Product Names GDF15, Growth and Differentiation Factor 15 Recombinant, GDF-15, MIC1, MIC-1, NAG-1, PDF, PLAB, PTGFB, Growth/differentiation factor 15, Placental bone morphogenetic protein, Placental TGF-beta, Macrophage inhibitory cytokine 1, Prostate differentiation f
Gene Symbol GDF15
Gene id 9518
Alias Symbols GDF-15, MIC1, MIC-1, NAG-1, PDF, PLAB, PTGFB, Growth/differentiation factor 15, Placental bone morphogenetic protein, Placental TGF-beta, Macrophage inhibitory cytokine 1, Prostate differentiation factor, NSAID-activated gene 1 protein, NSAID
Swissprot ID Q99988
Protein Name Growth/differentiation factor 15
Description of Target Recombinant Human Growth and Differentiation factor 15
Protein Accession Num NP_004855.2
Host E. Coli
Peptide Sequence MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMARA RNGDHCPLGP GRCCRLHTVR ASLEDLGWAD WVLSPREVQV TMCIGACPSQ FRAANMHAQI KTSLHRLKPD TVPAPCCVPA SYNPMVLIQK TDTGVSLQTY DDLLAKDCHC I.
Product Format The GDF15 protein solution contains 10mM sodium citrate, pH-3.5 & 10% glycerol. Physical appearance: Sterile filtered colorless solution.
Purity Greater than 95.0% as determined by SDS-PAGE.
Format The GDF15 protein solution contains 10mM sodium citrate, pH-3.5 & 10% glycerol.
Reconstitution and Storage Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for GWB-1F9A4A
Storage Store at 4C if entire vial will be used within 2-4 weeks. Store frozen at -20C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Lead Time Domestic: within 1-2 weeks delivery | International: 1-2 weeks
Intended Use Research Use Only
:: Biological Activity: Specific activity is 2.8-3.3 units/mg, and is defined as the amount of enzyme that conjugate 1.0 u mole of 1-chloro-2,4-dinitrobenzene (CDNB) with reduced glutathione per minute at pH 6.5 at 25C.
:: Product Introduction: GDF15 is part of the TGF-Beta superfamily that is involved in regulating inflammatory and apoptotic pathways in injured tissues and throughout disease processes. GDF15 is most abundant in the liver. Its expression in liver can be considerably up-regulated in during injury of organs such as liver, kidney, heart and lung. GDF-15 promotes proliferation or growth arrest and differentiation due to differences in cellular differentiation. GDF15 prevents apoptosis in cerebellar granule neurons by activating Akt and inhibiting endogenously active ERK. GDF15 is a novel autocrine/endocrine factor that antagonizes the hypertrophic response and loss of ventricular performance.
Product Description: Recombinant Human GDF15 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 151 amino acids (195-308) and having a molecular mass of 16.7 kDa.GDF15 is expressed with a 36 amino acid His tag fused at N-Terminus and purified by proprietary chromatographic techniques.