Raptor Antibody (GWB-4B61F7)

GWB-4B61F7

20-203-420309

0.1 ml
$294.00

Description

Clone ID: EP539Y

Immunogen: A synthetic peptide corresponding to residues near the C-terminus of human Raptor was used as immunogen. Specificity: A synthetic peptide corresponding to residues near the C-terminus of human Raptor was used as immunogen. Dilution: WB: 1:500
IHC: 1:50-100
ICC: 1:100-250
FC: 1:30
IP: 1:30. Raptor (regulatory associated protein of TOR) is a conserved 150 kDa adaptor protein composed of a unique conserved region, three HEAT repeats and seven WD-40 repeats (1). Raptor recruits mTOR substrates S6K1 (p70 S6 kinase) and 4E-BP1, and regulates mTOR kinase activity (2-3). Even though Raptor is a positive regulator of mTOR, it has been shown that under nutrient deprivation, the Raptor-mTOR association is stabilized in a manner that inhibits mTOR kinase activity (1). Raptor association with mTOR is required for efficient S6K1 and 4E0BP1 phosphorylation (4). 1. D.H. Kim, D.D. Sarbassov, S.M. Ali, J.E. King, R.R. Latek, H. Erdjument-Bromage, P. Tempst and D.M. Sabatini. Cell 110 (2002), pp. 163
2. Kim, D. H., Sarbassov, D. D., Ali, S. M., Latek, R. R., Guntur, K. V., Erdjument-Bromage, H., Tempst, P., and Sabatini, D. M. (2003) Mol. Cell 11, 895-904
3. Hara, K., Maruki, Y., Long, X., Yoshino, K., Oshiro, N., Hidayat, S., Tokunaga, C., Avruch, J., and Yonezawa, K. (2002) Cell 110, 177-189
4. Beugnet, A., Wang, X., and Proud, C.G. 2003. J. Biol. Chem. 278: 40717-40722.
5. Manufactured under U.S. Patents, No. 5,675,063 and 7,429,487

Additional Information

Name Raptor Antibody (GWB-4B61F7)
Availability Discontinued
Related Product Names Raptor Rabbit Monoclonal Antibody RPTOR, KIAA1303, RAPTOR, Regulatory-associated protein of mTOR, P150 target of rapamycin (TOR)-scaffold proteinRaptor
Swissprot ID Q8N122
Molecular Weight 150 kDa
Source Rabbit
Application WB, IHC, ICC, FC, IP
Clonality Monoclonal
Reactivity Human
Storage Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Datasheets/Manuals Printable datasheet for GWB-4B61F7
Intended Use Research Use Only