RAPTOR BLOCKING PEPTIDE (GWB-9538F0)

GWB-9538F0

06-783-313211

0.05 mg
$268.00

Description

Function: Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino-acids. Amino-acid-signaling to mTORC1 is mediated by Rag GTPases, which cause amino-acid-induced relocalization of mTOR within the endomembrane system. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Ref.1Ref.2

Additional Information

Name RAPTOR BLOCKING PEPTIDE (GWB-9538F0)
Availability Discontinued
Related Product Names KIAA1303RAPTOR BLOCKING PEPTIDERPTOR
Description of Target RAPTOR BLOCKING PEPTIDE
Gene Symbol RPTOR
Gene Family WDR
Gene id 57521
Alias Symbols KOG1, Mip1, KIAA1303, RPTOR
Swissprot ID Q8N122
Protein Accession Num NP_065812.1
Homology Human
Product Format Purified peptide - liquid
Application IP, WB
Clonality Blocking Peptide
Format Purified peptide - liquid
Stability 12 months from date of despatch
Reconstitution and Storage Store at +4oC only.
DO NOT FREEZE.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Reactivity Human
Storage Store at +4oC only.
DO NOT FREEZE.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Datasheets/Manuals Printable datasheet for GWB-9538F0
Species Reactivity Human
Intended Use Research Use Only