RABBIT ANTI TSC2 Antibody (GWB-E9A2ED)

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GWB-E9A2ED

18-783-313804

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$0.00

Description

Function: In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. Ref.15Ref.16Ref.18

Additional Information

Name RABBIT ANTI TSC2 Antibody (GWB-E9A2ED)
Related Product Names TSC4RABBIT ANTI TSC2TSC2
Description of Target RABBIT ANTI TSC2
Immunogen The immunogen for anti-TSC2 antibody: synthetic peptide corresponding to a 14 amino acid peptide from near the amino terminus of human TSC2.
Gene Symbol TSC2
Gene id 7249
Alias Symbols LAM, TSC4, FLJ43106, TSC2
Swissprot ID P49815
Protein Name Tuberin
Protein Accession Num NP_000539.2
Host Rabbit
Isotype Polyclonal IgG
Homology Human
Product Format Purified IgG - liquid
Specificity TSC2
Application P*, WB
Clonality Polyclonal Antibody
Format Purified IgG - liquid
Stability 18 months from date of despatch.
Reconstitution and Storage Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Reactivity Human
Application Info Immunohistology - Paraffin(1):    5 - ug/ml
Western Blotting:    1ug/ml
(1)Special conditions apply. See (*).
Storage Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product cont
Datasheets/Manuals Printable datasheet for GWB-E9A2ED
Species Reactivity Human
Intended Use Research Use Only
Additional Information Histology Positive Control Tissue: Human pancreas
:: Preservative Stabilisers: 0.02% Sodium Azide (NaN3)
Antiserum Preparation: Antiserum to human TSC2 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
:: Approx Protein Conc: IgG concentration 1.0mg/ml
Buffer Solutions: Phosphate buffered saline