Description
Function: In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. Ref.15Ref.16Ref.18
Additional Information
Name | RABBIT ANTI TSC2 Antibody (GWB-E9A2ED) |
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Related Product Names | TSC4RABBIT ANTI TSC2TSC2 |
Gene Symbol | TSC2 |
Gene id | 7249 |
Alias Symbols | LAM, TSC4, FLJ43106, TSC2 |
Swissprot ID | P49815 |
Protein Name | Tuberin |
Description of Target | RABBIT ANTI TSC2 |
Protein Accession Num | NP_000539.2 |
Application Info | Immunohistology - Paraffin(1): 5 - ug/ml Western Blotting: 1ug/ml (1)Special conditions apply. See (*). |
Host | Rabbit |
Immunogen | The immunogen for anti-TSC2 antibody: synthetic peptide corresponding to a 14 amino acid peptide from near the amino terminus of human TSC2. |
Isotype | Polyclonal IgG |
Homology | Human |
Product Format | Purified IgG - liquid |
Specificity | TSC2 |
Application | P*, WB |
Clonality | Polyclonal Antibody |
Format | Purified IgG - liquid |
Stability | 18 months from date of despatch. |
Reconstitution and Storage | Store at +4oC or at -20oC if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
Reactivity | Human |
Datasheets/Manuals | Printable datasheet for GWB-E9A2ED |
Storage | Store at +4oC or at -20oC if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product cont |
Species Reactivity | Human |
Lead Time | Domestic: within 2-3 weeks delivery | International: 2-3 weeks |
Intended Use | Research Use Only |
Additional Information | Histology Positive Control Tissue: Human pancreas |
:: | Preservative Stabilisers: 0.02% Sodium Azide (NaN3) Antiserum Preparation: Antiserum to human TSC2 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. |
:: | Approx Protein Conc: IgG concentration 1.0mg/ml Buffer Solutions: Phosphate buffered saline |