Description
Function: In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. Ref.15Ref.16Ref.18
Additional Information
| Name | RABBIT ANTI TSC2 Antibody (GWB-E9A2ED) |
|---|---|
| Related Product Names | TSC4RABBIT ANTI TSC2TSC2 |
| Description of Target | RABBIT ANTI TSC2 |
| Immunogen | The immunogen for anti-TSC2 antibody: synthetic peptide corresponding to a 14 amino acid peptide from near the amino terminus of human TSC2. |
| Gene Symbol | TSC2 |
| Gene id | 7249 |
| Alias Symbols | LAM, TSC4, FLJ43106, TSC2 |
| Swissprot ID | P49815 |
| Protein Name | Tuberin |
| Protein Accession Num | NP_000539.2 |
| Host | Rabbit |
| Isotype | Polyclonal IgG |
| Homology | Human |
| Product Format | Purified IgG - liquid |
| Specificity | TSC2 |
| Application | P*, WB |
| Clonality | Polyclonal Antibody |
| Format | Purified IgG - liquid |
| Stability | 18 months from date of despatch. |
| Reconstitution and Storage | Store at +4oC or at -20oC if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Reactivity | Human |
| Application Info | Immunohistology - Paraffin(1): 5 - ug/ml Western Blotting: 1ug/ml (1)Special conditions apply. See (*). |
| Storage | Store at +4oC or at -20oC if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product cont |
| Datasheets/Manuals | Printable datasheet for GWB-E9A2ED |
| Species Reactivity | Human |
| Intended Use | Research Use Only |
| Additional Information | Histology Positive Control Tissue: Human pancreas |
| :: | Preservative Stabilisers: 0.02% Sodium Azide (NaN3) Antiserum Preparation: Antiserum to human TSC2 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. |
| :: | Approx Protein Conc: IgG concentration 1.0mg/ml Buffer Solutions: Phosphate buffered saline |