A2M Protein (GWB-39F186) (Aviva Cat. No. OPPA01428)

This exact product is available to purchase through Aviva Systems Biology.
Please see item number OPPA01428 to view product details and for ordering information.


Aviva Cat. No.: OPPA01428



Human Alpha-2 Macroglobulin is a tetrameric glycoprotein, produced in Human plasma.

Additional Information

Name A2M Protein (GWB-39F186)
Related Product Names Alpha-2-macroglobulin, Alpha-2-M, A2M, CPAMD5, FWP007, S863-7, alpha 2M, DKFZp779B086
Gene Symbol A2M
Gene id 2
Swissprot ID P01023
Protein Name Alpha-2-macroglobulin
Description of Target Alpha-2 Macroglobulin is a serine proteases inhibitor, which inhibits coagulation by inactivating thrombin and Kallikrein, it inhibits fibrinolysis by inactivating plasmin and involved in transport. Alpha-2-Macroglobulin is a large plasma protein, which is produced by the liver, it is composed of 4 identical subunits bound together by -S-S- bonds. A2M is able to inactivate many kinds of proteinases (including serine-, cysteine-, aspartic- and metalloproteinases). A2M has a 35 amino acid "bait" region in its structure. Proteinases bind and cleave the “bait” region become bound to A2M. Macrophage receptors recognize the proteinase-A2M complex and clear it from the system. A2M binds to and removes MMP-2 and MMP-9 (active forms of the gelatinase) from the circulation using scavenger receptors on the phagocytes. The levels of Alpha-2-macroglobulin are increased in nephrotic syndrome which is a condition where the kidneys start to leak out some of the smaller blood proteins. Due to its large size, A2-macroglobulin is retained in the bloodstream. Increased production of all proteins causes A2-macroglobulin concentration to increase. Chronic renal failure might lead to amyloid by alpha-2-macroglobulin. A2M is raised in cirrhosis, pregnancy and diabetes.
Protein Accession Num NP_000005.2
Product Format Lyophilized 5mM potassium phosphate buffer, pH 6.5 and 1:1 ratio (w/w) of Glycine
Physical appearance: Sterile filtered white powder
Molecular Weight 725 kDa
Concentration 4.8 mg/ml (prior to lyophilization)
Purity > 95.0% as determined by Analysis by SDS-PAGE
Source Human Plasma
Reconstitution and Storage It is recommended to reconstitute the lyophilized A2M in sterile 18MΩ-cm H2O. Lyophilized A2M protein although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution and filter sterilization A2M can be stored at 4°C for up to 4 weeks. For long term storage and more diluted solutions it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for GWB-39F186
Lead Time Domestic: within 1-2 weeks delivery | International: 1-2 weeks
Intended Use Research Use Only
Additional Information Human Virus Test: Serum from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV and HBV.