A2M Protein (GWB-39F186) (Aviva Cat. No. OPPA01428)

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GWB-39F186

Aviva Cat. No.: OPPA01428

11-663-46208

Description

Human Alpha-2 Macroglobulin is a tetrameric glycoprotein, produced in Human plasma.

Additional Information

Name A2M Protein (GWB-39F186)
Related Product Names Alpha-2-macroglobulin, Alpha-2-M, A2M, CPAMD5, FWP007, S863-7, alpha 2M, DKFZp779B086
Gene Symbol A2M
Gene id 2
Swissprot ID P01023
Protein Name Alpha-2-macroglobulin
Description of Target Alpha-2 Macroglobulin is a serine proteases inhibitor, which inhibits coagulation by inactivating thrombin and Kallikrein, it inhibits fibrinolysis by inactivating plasmin and involved in transport. Alpha-2-Macroglobulin is a large plasma protein, which is produced by the liver, it is composed of 4 identical subunits bound together by -S-S- bonds. A2M is able to inactivate many kinds of proteinases (including serine-, cysteine-, aspartic- and metalloproteinases). A2M has a 35 amino acid "bait" region in its structure. Proteinases bind and cleave the “bait” region become bound to A2M. Macrophage receptors recognize the proteinase-A2M complex and clear it from the system. A2M binds to and removes MMP-2 and MMP-9 (active forms of the gelatinase) from the circulation using scavenger receptors on the phagocytes. The levels of Alpha-2-macroglobulin are increased in nephrotic syndrome which is a condition where the kidneys start to leak out some of the smaller blood proteins. Due to its large size, A2-macroglobulin is retained in the bloodstream. Increased production of all proteins causes A2-macroglobulin concentration to increase. Chronic renal failure might lead to amyloid by alpha-2-macroglobulin. A2M is raised in cirrhosis, pregnancy and diabetes.
Protein Accession Num NP_000005.2
Product Format Lyophilized 5mM potassium phosphate buffer, pH 6.5 and 1:1 ratio (w/w) of Glycine
Physical appearance: Sterile filtered white powder
Molecular Weight 725 kDa
Concentration 4.8 mg/ml (prior to lyophilization)
Purity > 95.0% as determined by Analysis by SDS-PAGE
Source Human Plasma
Reconstitution and Storage It is recommended to reconstitute the lyophilized A2M in sterile 18MΩ-cm H2O. Lyophilized A2M protein although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution and filter sterilization A2M can be stored at 4°C for up to 4 weeks. For long term storage and more diluted solutions it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for GWB-39F186
Lead Time Domestic: within 1-2 weeks delivery | International: 1-2 weeks
Intended Use Research Use Only
Additional Information Human Virus Test: Serum from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV and HBV.