Alkaline Phosphatase Human (GWB-6D09AD)

GWB-6D09AD

11-511-248020

100 Units
$63.00

Description

Alkaline Phosphatase, Human.
Alkaline Phosphatase, Human Placenta

Concentration: 0.83mg protein/vial (Coomassie) Activity: 120U/mg protein One unit will convert one micromole of p-nitrophenyl phosphate to p-nitrophenol and phosphate per minute at 37C in the presence of AMP (2-amino-2-methyl-1-propanol) at pH 10.35.

Inactivation: Not applicable

Buffer: Lyophilized from 25mM Tris, 1mM Magnesium, 0.1mM Zinc, pH 7.6

Applications Notes : Specific methodologies have not been tested using this product.

Preservative: None

Function: This isozyme may play a role in skeletal mineralization.

Catalytic Activity: A phosphate monoester + H2O = an alcohol + phosphate.

Cofactor: Binds 1 magnesium ion (By similarity).

Cofactor: Binds 2 zinc ions (By similarity).

Subunit: Homodimer.

Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor.

Ptm: Glycosylated.

Disease: Defects in ALPL are a cause of hypophosphatasia infantile (hypophosphatasia) [MIM:241500]; an inherited metabolic bone disease characterized by defective skeletal mineralization. Four hypophosphatasia forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. Patients with only premature loss of deciduous teeth, but with no bone disease are regarded as having odontohypophosphatasia (odonto).

Disease: Defects in ALPL are a cause of hypophosphatasia childhood (hypophosphatasia) [MIM:241510].

Disease: Defects in ALPL are a cause of hypophosphatasia adult type (hypophosphatasia) [MIM:146300].

Miscellaneous: In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).

Similarity: Belongs to the alkaline phosphatase family.

Additional Information

Name Alkaline Phosphatase Human (GWB-6D09AD)
Related Product Names Alkaline Phosphatase, Human; EC 3.1.3.1; AP-TNAP; TNSALP; Alkaline phosphatase liver/bone/kidney isozyme Alkaline Phosphatase, HumanALPL
Swissprot ID P05186
NCBI Acc Number NP_000469.3
Molecular Weight 57305
Source Human Placenta
Format Purified, LyophilizedReconstitute with Tris saline or other buffer to desired concentration.
Storage Store at -20 C.
Datasheets/Manuals Printable datasheet for GWB-6D09AD
Intended Use Research Use Only