Inactivation: Not applicable
Buffer: Lyophilized from 20mM Tris, pH 8.0 containing 600mM Sodium Chloride, 2mM CaCl2 and 20% sucrose
Applications Notes : Specific methodologies have not been tested using this product.
Concentration: Concentration is lot specific
Human Thrombospondin. . A cellular adhesion protein. Thrombospondin is a component of the coagulation mechanism and is believed to have potential as a marker for platelet activation and renal failure.
Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3.
Subunit: Homotrimer; disulfide-linked.
Similarity: Belongs to the thrombospondin family.
Similarity: Contains 3 EGF-like domains.
Similarity: Contains 1 TSP C-terminal (TSPC) domain.
Similarity: Contains 1 TSP N-terminal (TSPN) domain.
Similarity: Contains 3 TSP type-1 domains.
Similarity: Contains 8 TSP type-3 repeats.
Similarity: Contains 1 VWFC domain.