Mouse PAI-1 (GWB-234F01)



500 ug
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Specificity: Plasminogen Activator Inhibitor 1, Recombinant

Preservative: None Inactivation: Not applicable

Buffer: 0.05M Sodium acetate, 0.1M Sodium chloride, 1mM EDTA, pH 5.0

Applications Notes : Specific methodologies have not been tested using this product. Concentration: Concentration is lot specific Mouse PAI-1, Recombinant. Mouse Plasminogen Activator Inhibitor 1 (PAI-1) (wild type), Recombinant. Does not contain a fusion partner. Molecular weight: 43kDa

Function: This inhibitor acts as \'bait\' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis.

Subunit: Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation.

Subcellular Location: Secreted.

Tissue Specificity: Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells.

Ptm: Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond.

Disease: Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) [MIM:173360]. This deficiency is characterized by abnormal bleeding due to SERPINE1 defect in the plasma.

Disease: High concentrations of SERPINE1 have been associated with thrombophilia [MIM:188050]; an autosomal dominant disorder in which affected individuals are prone to develop serious spontaneous thrombosis.

Similarity: Belongs to the serpin family.

Additional Information

Name Mouse PAI-1 (GWB-234F01)
Related Product Names Mouse PAI-1, Recombinant; PAI-1; PAI; Endothelial plasminogen activator inhibitor PAI1; PLANH1Mouse PAI-1,SERPINE1
Swissprot ID P05121
NCBI Acc Number NP_000593.1
Molecular Weight 45060
Purity >98% pure (SDS-PAGE). 80 + 5% active by uPA titration. Column chromatography
Source E. Coli
Format Purified, Liquid
Storage Store at -70 C. Avoid multiple freeze/thaw cycles.
Datasheets/Manuals Printable datasheet for GWB-234F01
Intended Use Research Use Only