tPA Protein (GWB-2067B9) (Aviva Cat. No. OPPA00785)

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GWB-2067B9

Aviva Cat. No.: OPPA00785

10-663-45291

Additional Information

Name tPA Protein (GWB-2067B9)
Gene Symbol tPA
Gene id 5327
Alias Symbols Tissue-type plasminogen activator, EC 3.4.21.68, tPA, t-PA, t-plasminogen activator, TPA, T-PA, DKFZp686I03148, tPA Human, Tissue Plasminogen Activator Human Recombinant
Swissprot ID P00750
Protein Name Tissue-type plasminogen activator
Description of Target Tissue plasminogen activator (abbreviated PLAT or tPA) is a secreted serine protease which converts the proenzymeplasminogento plasmin, a fibrinolyticenzyme. Plasminogen is synthesized as a single chain which is cleaved by PLAT into the two chain disulfide linked plasmin. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosisor embolism.
Protein Accession Num NP_000921.1
NCBI Acc Number NP_000921.1
Product Format Lyophilized Each mg of tPA contains 1.7 grams L-arginine, 0.5 g phosphoric acid and 4 mg tween 80
Physical Appearance: Sterile filtered white powder
Molecular Weight 59 kDa
Purification Purified by proprietary chromatographic techniques.
Biological Activity Enzymatic Activity: 580,000 IU/mg
Purity ≥ 98.0% as determined by:
(a) Analysis by RP-HPLC
(b) Analysis by SDS-PAGE.
Source Chinese Hamster Ovarian Cells (CHO)
Reconstitution and Storage It is recommended to reconstitute the lyophilized t-PA in sterile 18MΩcm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Lyophilized t-PA although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution tPA should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for GWB-2067B9
Lead Time Domestic: within 1-2 weeks delivery | International: 1-2 weeks
Intended Use Research Use Only