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Tryptophan 2 3-dioxygenase

GWB-11449C

10-288-22428F

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Description

Fusion T7 tag at N-terminus.
Catalytic Activity L-tryptophan + O2 = L-formylkynurenine.
Cofactor Binds 2 heme groups per tetramer. The hemes are protoheme IV (By similarity).
Pathway Tryptophan catabolism.
Subunit Homotetramer (By similarity).
Miscellaneous Broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin.
Reference
  1. Guillemin,G.J., Smythe,G., Takikawa,O. and Brew,B.J., et al.
    Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons
  2. Nabi,R., Serajee,F.J., Chugani,D.C., Zhong,H. and Huq,A.H., et al.
    Association of tryptophan 2,3 dioxygenase gene polymorphism with autism
  3. Kudo,Y., Boyd,C.A., Sargent,I.L. and Redman,C.W., et al.
    Decreased tryptophan catabolism by placental indoleamine 2,3-dioxygenase in preeclampsia
  4. Dick,R., Murray,B.P., Reid,M.J. and Correia,M.A., et al.
    Structure--function relationships of rat hepatic tryptophan 2,3-dioxygenase: identification of the putative heme-ligating histidine residues
  5. Comings,D.E., Muhleman,D., Dietz,G., Sherman,M. and Forest,G.L., et al.
    Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat
  6. Comings D.E., Muhleman D., Dietz G., Sherman M., Forest G.L.
    Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat.
  7. Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., et al.
    Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.

Additional Information

Name Tryptophan 2 3-dioxygenase
Related Product Names EC 1.13.11.11; Tryptophan pyrrolase; Tryptophanase; Tryptophan oxygenase; Tryptamin 2,3-dioxygenase; TRPO TDO; TPH2Tryptophan 2,3-dioxygenaseTDO2
NCBI Acc Number NP_005642.1
Molecular Weight 47872
Datasheets / Downloads GWB-11449C Datasheet
Swiss Prot Number P48775
Purity 95%
Source E Coli
Applications MS, SDS
GI Number 5032165
Format 10 mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% NaN3, 10mM DTT.
Stability 6-12 months at -70 degree C.
Reactivity human
Sequence Length 406
Chrom Location 4q31-q32
Storage -70 degree C. Avoid frequent freeze and thaw.
Intended Use Research Use Only