Sarafotoxin 6c

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Sequence (One Letter Code): CTCNDMTDEECLNFCHQDVIW (Disulfide bridge: 1-15 and 3-11)

Sequence: {CYS} {THR} {CYS} {ASN} {ASP} {MET} {THR} {ASP} {GLU} {GLU} {CYS} {LEU} {ASN} {PHE} {CYS} {HIS} {GLN} {ASP} {VAL} {ILE} {TRP} Formula: C103H147N27O37S5 Chemical Bridge: 1-15 and 3-11

Solubility: InSoluble in water. Peptide is very acidic.Rehydrate 100mg of peptide with at least 1ml of pH 8.0 buffer orrehydrate the content with 30ml-100ml DMSO - then dilute up the content with water to the desired concentration. S6c. as a selective ETB endothelin receptor agonist. its administration can cause a transient fall in mean arterial blood pressure (MABP) prior to occlusion and attenuated the fall in MABP induced by coronary occlusion.

Function: Vasoconstrictor activity. These toxins cause cardiac arrest probably as a result of coronary vasospasm.

Subcellular Location: Secreted protein.

Toxic Dose: LD50 is 0.015 mg/kg by intravenous injection for sarafotoxin-A and sarafotoxin-B, and 0.3 mg/kg for sarafotoxin-C.

Similarity: Belongs to the endothelin/sarafotoxin family. [1] Takasaki,C., Itoh,Y., Onda,H. and Fujino,M., et al.
Cloning and sequence analysis of a snake, Atractaspis engaddensis gene encoding sarafotoxin S6c
[2] Itoh,Y., et al.
Direct Submission
[3] Ducancel F., Matre V., Dupont C., Lajeunesse E., Wollberg Z., Bdolah A., Kochva E., Boulain J.-C., Menez A.
Cloning and sequence analysis of cDNAs encoding precursors of sarafotoxins. Evidence for an unusual \'rosary-type\' organization.
[4] Takasaki C., Tamiya N., Bdolah A., Wollberg Z., Kochva E.
Sarafotoxins S6: several isotoxins from Atractaspis engaddensis (burrowing asp) venom that affect the heart.
[5] Kloog Y., Ambar I., Sokolovsky M., Kochva E., Wollberg Z., Bdolah A.
Sarafotoxin, a novel vasoconstrictor peptide: phosphoinositide hydrolysis in rat heart and brain.
[6] Takasaki C., Itoh Y., Onda H., Fujino M.
Cloning and sequence analysis of a snake, Atractaspis engaddensis gene encoding sarafotoxin S6c.
[7] Mills R.G., Atkins A.R., Harvey T., Junius F.K., Smith R., King G.F.
Conformation of sarafotoxin-6b in aqueous solution determined by NMR spectroscopy and distance geometry.
[8] Aumenas A., Chiche L., Mahe E., le Nguyen D., Sizun P., Bethault P., Perly B.
1H NMR study of the solution structure of sarafotoxin-S6b.
[9] Aimoto S., Hojoh H., Takasaki C.
Studies on the disulfide bridges of sarafotoxins. Chemical synthesis of sarafotoxin S6B and its homologue with different disulfide bridges.

Additional Information

Name Sarafotoxin 6c
Related Product Names Sarafotoxin 6c
Intended Use Research Use Only
NCBI Acc Number BAA02579.2
GI Number 16751519
Purity > 95%
Stability 6-12 months at -20 degree C.
Storage 4 degree C for short term (weeks) and -20 degree C for long term.
Molecular Weight 62326
Sequence Length 23
Swiss Prot Number P13208