Crossreactivity Note: Minimal cross reaction to human, rat and mouse serum proteins
Characterization: To insure lot-to-lot consistency, each batch of product is tested by ELISA and/or PCFIA for conformance to characteristics of a standard reference reagent.
Crossreactivity Notes: Minimal cross reaction to human, rat and mouse serum proteins Specificity: Reacts with the heavy and light chains of goat IgG as demonstrated by ELISA. May also react with the light chains of other goat immunoglobulins. Working Dilution: Immunofluorescence 0.1 ug/10^6 cells
Warning: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing. Subcellular Location: Secreted.
Disease: Chromosomal aberrations involving IGHG1 may be a cause of multiple myeloma [MIM:254500]. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
Miscellaneous: Nie has the G1M(17) allotypic marker, 97-K, and the G1M(1) markers, 239-D and 241-L. KOL and EU sequences have the G1M(3) marker and the G1M (non-1) markers.
Miscellaneous: Nie also differs in the amidation states of 35, 116, 198, 269 and 272.
Miscellaneous: EU also differs in the amidation states of residues 155, 166, 177, 195, 198, 269, and 272 and in the order of residues 268-272.
Miscellaneous: KOL also differs in the amidation states of residues 198, 267 and 272.