SKP2 p19 Antibody (GWB-843F3B)



7 ml


Isotype: Rabbit IgG Positive Control: Prostate

Cellular Localization: Nuclear and cytoplasmic

Immunogen: Recombinant protein encoding aa 221-425 of human Skp2 alpha. Skp2 (S-phase Kinase-associated Protein 2) belongs to the family of F-box proteins that interact with the Cyclin A-Cdk2 complex. Skp2 is essential for the G1-S transition in both transformed cells and diploid fibroblasts. Biochemical and genetic experiments have demonstrated that Skp2 is required for the ubiquitination and consequent degradation of p27 in cultured mammalian cells and in vitro reconstitution assays. In normal tissues, Skp2 is expressed in tonsil and placenta. In tumor tissues, Skp2 is expressed widely, in some colon, prostate, pancreas, and skin cancers, with high expression in lung, breast, ovarian, and endometrial cancers. Research suggests that Skp2 plays a role in oncogenesis, particularly in the pathogenesis of lymphomas and breast cancers.

Additional Information

Name SKP2 p19 Antibody (GWB-843F3B)
Related Product Names SKP2 ALPHA RABBIT ANTIBODY SKP2 p19
Source Rabbit
Application IHC-P
Format 7.0 ml prediluted antibody which is ready-to-use for staining of formalin-fixed, paraffin-embedded tissues.
Reactivity Human
Datasheets/Manuals Printable datasheet for GWB-843F3B
Storage Ab with sodium azide is stable for 24 months when stored at 2-8C.
Intended Use Research Use Only