VEGFR2 (Phospho-Tyr1214)

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VEGFR2 (Phospho-Tyr1214) - GenWay (GWB-6D861A)


Binding Site: Tyr1214 WB Dilution: 500~1000

IHC Dilution: 50~100 Function: Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi\'s sarcoma lesions.

Catalytic Activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit: Interacts with SHB upon VEGF activation. Interacts with HIV-1 Tat.

Subcellular Location: Membrane; Single-pass type I membrane protein.

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.

Similarity: Contains 7 Ig-like C2-type (immunoglobulin-like) domains.

Similarity: Contains 1 protein kinase domain. [1] Yin L.Y., Wu Y., Patterson C.
Full length human KDR/flk-1 sequence.
[2] Yu Y., Whitney R.G., Sato J.D.
Coding region for human VEGF receptor KDR (VEGFR-2).
[3] Terman B.I., Carrion M.E., Kovacs E., Rasmussen B.A., Eddy R.L., Shows T.B.
Identification of a new endothelial cell growth factor receptor tyrosine kinase.
[4] Patterson C., Perrella M.A., Hsieh C.-M., Yoshizumi M., Lee M.-E., Harber E.
Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor.
[5] Terman B.I., Dougher-Vermazen M., Carrion M.E., Dimitrov D., Armellino D.C., Gospodarowicz D., Boehlen P.
Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor.
[6] Mitola S., Soldi R., Zanon I., Barra L., Gutierrez M.I., Berkhout B., Giacca M., Bussolino F.
Identification of specific molecular structures of human immunodeficiency virus type 1 Tat relevant for its biological effects on vascular endothelial cells.
[7] Holmqvist K., Cross M.J., Rolny C., Haegerkvist R., Rahimi N., Matsumoto T., Claesson-Welsh L., Welsh M.
The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration.

Additional Information

Name VEGFR2 (Phospho-Tyr1214)
Related Product Names EC; VEGFR-2; Kinase insert domain receptor; Protein-tyrosine kinase receptor Flk-1; CD309 antigen FLK1VEGFR2 (Phospho-Tyr1214)VEGFR2
Intended Use Research Use Only
Purity Affinity Purified
Format In PBS, 0.02% sodium azide and 50% glycerol.
Stability 1 year at -20C
Clonality Polyclonal
Storage 4C for short term (weeks) and -20C for long term. Avoid frequent freeze and thaw.
Molecular Weight 151527
Swiss Prot Number P35968
Applications IHC