Binding Site: Tyr1214 WB Dilution: 500~1000
IHC Dilution: 50~100 Function: Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi\'s sarcoma lesions.
Catalytic Activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit: Interacts with SHB upon VEGF activation. Interacts with HIV-1 Tat.
Subcellular Location: Membrane; Single-pass type I membrane protein.
Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Similarity: Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
Similarity: Contains 1 protein kinase domain.  Yin L.Y., Wu Y., Patterson C.
Full length human KDR/flk-1 sequence.
 Yu Y., Whitney R.G., Sato J.D.
Coding region for human VEGF receptor KDR (VEGFR-2).
 Terman B.I., Carrion M.E., Kovacs E., Rasmussen B.A., Eddy R.L., Shows T.B.
Identification of a new endothelial cell growth factor receptor tyrosine kinase.
 Patterson C., Perrella M.A., Hsieh C.-M., Yoshizumi M., Lee M.-E., Harber E.
Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor.
 Terman B.I., Dougher-Vermazen M., Carrion M.E., Dimitrov D., Armellino D.C., Gospodarowicz D., Boehlen P.
Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor.
 Mitola S., Soldi R., Zanon I., Barra L., Gutierrez M.I., Berkhout B., Giacca M., Bussolino F.
Identification of specific molecular structures of human immunodeficiency virus type 1 Tat relevant for its biological effects on vascular endothelial cells.
 Holmqvist K., Cross M.J., Rolny C., Haegerkvist R., Rahimi N., Matsumoto T., Claesson-Welsh L., Welsh M.
The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration.