Specificity: Vitamin D Binding Protein (Gc-Globulin)
Preservative: None Inactivation: Not applicable.
Buffer: Lyophilized from 20mM Sodium Phosphate, pH 7.4 containing 150mM Sodium chloride
Applications Notes : Specific methodologies have not been tested using this product. Concentration: Concentration is lot specific
Description: Molecular weight 52kDa (SDS-PAGE, reducing conditions) Vitamin D Bind.Prot (GC-Glob.). Purified Vitamin D Binding Protein (GC Globulin). Molecular weight 52kDa (SDS-PAGE, reducing conditions)
Function: Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.
Subcellular Location: Secreted.
Polymorphism: Over 80 variants of human DBP have been identified. The three most common alleles are called GC*1F, GC*1S, and GC*2. The sequence shown is that of the GC*2 allele.
Similarity: Belongs to the ALB/AFP/VDB family.
Similarity: Contains 3 albumin domains.